Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

RELN signaling modulates glioblastoma growth and substrate-dependent migration

(2018) Markus Schulze et al.   BRAIN PATHOLOGY

Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation

(2018) Yue Ding et al.   Cell Death & Disease

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

(2018) Ping Wang et al.   Protein & Cell

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

(2018) Si Wang et al.   Cell Discovery

Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction

(2018) Yukun Zhu et al.   BIOGERONTOLOGY

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice

(2018) Iole Ferrara-Romeo et al.   PLoS One

Chemical screen identifies a geroprotective role of quercetin in premature aging

(2018) Lingling Geng et al.   Protein & Cell

Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia

(2017) Rahim Mohd Nabil Fikri et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

(2017) Marianna Feretzaki et al.   METHODS

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids

(2017) Vishal Nanavaty et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

(2017) Lu Xiao et al.   Cell Death & Disease

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

(2017) Hyeung Kim et al.   Cell Discovery

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

(2016) Paula Martínez et al.   AGING CELL

Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells

(2016) P.J. Hohensinner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin

(2016) Jigar N. Bandaria et al.   CELL

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

Shelterin

(2016) Isabelle Schmutz et al.   CURRENT BIOLOGY

Differential methylation at the RELN gene promoter in temporal cortex from autistic and typically developing post-puberal subjects

(2016) Carla Lintas et al.   Journal of Neurodevelopmental Disorders

Reelin and Neuropsychiatric Disorders

(2016) Kazuhiro Ishii et al.   Frontiers in Cellular Neuroscience

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

(2016) Lina Fu et al.   Protein & Cell

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

The asymmetry of telomere replication contributes to replicative senescence heterogeneity

(2015) Thibault Bourgeron et al.   Scientific Reports

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

(2014) Roger Reddel   CURRENT PHARMACEUTICAL DESIGN

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?

(2014) Katsutoshi Sekine et al.   NEUROSCIENCE RESEARCH

Downregulation of Rap1 promotes 5-fluorouracil-induced apoptosis in hepatocellular carcinoma cell line HepG2

(2014) YONG ZHA et al.   ONCOLOGY REPORTS

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

(2014) Guang-Hui Liu et al.   Nature Communications

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence

(2013) Zhou Xu et al.   GENETICS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

Pax8 has a critical role in epithelial cell survival and proliferation

(2013) T Di Palma et al.   Cell Death & Disease

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Interpretation of Genomic Variants Using a Unified Biological Network Approach

(2013) Ekta Khurana et al.   PLoS Computational Biology

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

(2012) G. Ha et al.   GENOME RESEARCH

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma

(2011) A. Vincent et al.   CLINICAL CANCER RESEARCH

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Genome-wide profiling at methylated promoters in pancreatic adenocarcinoma

(2010) Noriyuki Omura et al.   CANCER BIOLOGY & THERAPY

Taking apart Rap1

(2010) Shaheen Kabir et al.   CELL CYCLE

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei

(2009) Xiaofeng Yang et al.   CELL

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

(2008) M. Kundakovic et al.   MOLECULAR PHARMACOLOGY

A rapid micro chromatin immunoprecipitation assay (ChIP)

(2008) John Arne Dahl et al.   Nature Protocols

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY