Gliding motility powers invasion and egress in Apicomplexa

Direct measurement of cortical force generation and polarization in a living parasite

(2017) Rachel V. Stadler et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

(2017) Kevin M. Brown et al.   mBio

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

(2017) Karine Frénal et al.   Nature Communications

A unique profilin-actin interface is important for malaria parasite motility

(2017) Catherine A. Moreau et al.   PLoS Pathogens

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

(2017) Xavier Sisquella et al.   eLife

Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation

(2017) Javier Periz et al.   eLife

Coupling of Retrograde Flow to Force Production During Malaria Parasite Migration

(2016) Katharina A. Quadt et al.   ACS Nano

Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces

(2016) Marion Bichet et al.   BMC BIOLOGY

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion

(2016) Damien Jacot et al.   Cell Host & Microbe

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

(2016) Jennifer C. Volz et al.   Cell Host & Microbe

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma

(2016) Hayley E. Bullen et al.   Cell Host & Microbe

Reassessing the mechanics of parasite motility and host-cell invasion

(2016) Isabelle Tardieux et al.   JOURNAL OF CELL BIOLOGY

Calcium signalling in malaria parasites

(2016) Mathieu Brochet et al.   MOLECULAR MICROBIOLOGY

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Progress in imaging methods: insights gained into Plasmodium biology

(2016) Mariana De Niz et al.   NATURE REVIEWS MICROBIOLOGY

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail

(2016) Shruthi Krishnamurthy et al.   mBio

Gliding Associated Proteins Play Essential Roles during the Formation of the Inner Membrane Complex of Toxoplasma gondii

(2016) Clare R. Harding et al.   PLoS Pathogens

The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells

(2016) Arnault Graindorge et al.   PLoS Pathogens

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites

(2016) Kartik S. Bane et al.   PLoS Pathogens

Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton

(2016) Elizabeth S. Zuccala et al.   Scientific Reports

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

(2015) Sebastian Lourido et al.   CELL CALCIUM

ThePlasmodiumClass XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain

(2015) Noor A. Yusuf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion

(2015) David T. Riglar et al.   JOURNAL OF CELL SCIENCE

The apicomplexan glideosome and adhesins – Structures and function

(2015) Lauren E. Boucher et al.   JOURNAL OF STRUCTURAL BIOLOGY

Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane

(2015) David S. Gokhin et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct contribution ofToxoplasma gondiirhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion

(2015) George Rugarabamu et al.   MOLECULAR MICROBIOLOGY

Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair

(2015) Michelle L. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma Actin Is Required for Efficient Host Cell Invasion

(2015) Lisa L. Drewry et al.   mBio

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility

(2015) Melanie J. Williams et al.   mBio

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

(2015) Rajshekhar Y. Gaji et al.   PLoS Pathogens

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

(2015) Greta E. Weiss et al.   PLoS Pathogens

The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force

(2014) Marion Bichet et al.   BMC BIOLOGY

Calcium dynamics ofPlasmodium bergheisporozoite motility

(2014) Allison F. Carey et al.   CELLULAR MICROBIOLOGY

Quantitative analysis ofPlasmodiumookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility

(2014) Andrey Kan et al.   CELLULAR MICROBIOLOGY

Conditional expression of apical membrane antigen 1 inPlasmodium falciparumshows it is required for erythrocyte invasion by merozoites

(2014) Alan Yap et al.   CELLULAR MICROBIOLOGY

Assessment of phosphorylation inToxoplasmaglideosome assembly and function

(2014) Damien Jacot et al.   CELLULAR MICROBIOLOGY

Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress

(2014) Julien Salamun et al.   FASEB JOURNAL

AToxoplasma gondiiClass XIV Myosin, Expressed inSf9 Cells with a Parasite Co-chaperone, Requires Two Light Chains for Fast Motility

(2014) Carol S. Bookwalter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii

(2014) Qing Tang et al.   MOLECULAR BIOLOGY OF THE CELL

The Toxoplasma Acto-MyoA Motor Complex Is Important but Not Essential for Gliding Motility and Host Cell Invasion

(2014) Saskia Egarter et al.   PLoS One

Disruption of TgPHIL1 Alters Specific Parameters of Toxoplasma gondii Motility Measured in a Quantitative, Three-Dimensional Live Motility Assay

(2014) Jacqueline M. Leung et al.   PLoS One

Identification of T. gondii Myosin Light Chain-1 as a Direct Target of TachypleginA-2, a Small-Molecule Inhibitor of Parasite Motility and Invasion

(2014) Jacqueline M. Leung et al.   PLoS One

Toxoplasmaaldolase is required for metabolism but dispensable for host-cell invasion

(2014) Bang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion

(2014) B. Shen et al.   mBio

Plasticity and redundancy among AMA–RON pairs ensure host cell entry of Toxoplasma parasites

(2014) Mauld H. Lamarque et al.   Nature Communications

Plasmodium falciparum Erythrocyte Invasion: Combining Function with Immune Evasion

(2014) Gavin J. Wright et al.   PLoS Pathogens

Plasticity between MyoC- and MyoA-Glideosomes: An Example of Functional Compensation in Toxoplasma gondii Invasion

(2014) Karine Frénal et al.   PLoS Pathogens

The Apical Complex Provides a Regulated Gateway for Secretion of Invasion Factors in Toxoplasma

(2014) Nicholas J. Katris et al.   PLoS Pathogens

Multimeric Assembly of Host-Pathogen Adhesion Complexes Involved in Apicomplexan Invasion

(2014) May M. Paing et al.   PLoS Pathogens

Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity

(2014) Marijo S. Roiko et al.   PLoS Pathogens

RON5 Is Critical for Organization and Function of the Toxoplasma Moving Junction Complex

(2014) Josh R. Beck et al.   PLoS Pathogens

Structural Differences Explain Diverse Functions of Plasmodium Actins

(2014) Juha Vahokoski et al.   PLoS Pathogens

Recent insights into apicomplexan parasite egress provide new views to a kill

(2013) Michael J Blackman et al.   CURRENT OPINION IN MICROBIOLOGY

Un complexe moléculaire unique à l’origine de la motilité et de l’invasion des Apicomplexes

(2013) Karine Frénal et al.   M S-MEDECINE SCIENCES

A Novel High Throughput Invasion Screen Identifies Host Actin Regulators Required for Efficient Cell Entry by Toxoplasma gondii

(2013) Rajshekhar Y. Gaji et al.   PLoS One

The unusual dynamics of parasite actin result from isodesmic polymerization

(2013) Kristen M. Skillman et al.   Nature Communications

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

(2013) Swati Garg et al.   Nature Communications

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion

(2013) Daniel Y. Bargieri et al.   Nature Communications

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Toxoplasma gondii Profilin Acts Primarily To Sequester G-Actin While Formins Efficiently Nucleate Actin Filament Formation in Vitro

(2012) Kristen M. Skillman et al.   BIOCHEMISTRY

A Tetracycline-Repressible Transactivator System to Study Essential Genes in Malaria Parasites

(2012) Paco Pino et al.   Cell Host & Microbe

A Plasmodium Calcium-Dependent Protein Kinase Controls Zygote Development and Transmission by Translationally Activating Repressed mRNAs

(2012) Sarah Sebastian et al.   Cell Host & Microbe

Distinct signalling pathways controlToxoplasmaegress and host-cell invasion

(2012) Sebastian Lourido et al.   EMBO JOURNAL

Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?

(2012) Damien Jacot et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Characterization ofPlasmodium falciparumCalcium-dependent Protein Kinase 1 (PfCDPK1) and Its Role in Microneme Secretion during Erythrocyte Invasion

(2012) Abhisheka Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms

(2012) Nicole Andenmatten et al.   NATURE METHODS

Spatial Localisation of Actin Filaments across Developmental Stages of the Malaria Parasite

(2012) Fiona Angrisano et al.   PLoS One

Subcellular Location, Phosphorylation and Assembly into the Motor Complex of GAP45 during Plasmodium falciparum Schizont Development

(2012) Mohd A. Mohd Ridzuan et al.   PLoS One

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis

(2012) A. Farrell et al.   SCIENCE

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

(2012) Brigitte Vulliez-Le Normand et al.   PLoS Pathogens

Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity

(2012) Ijeoma Ejigiri et al.   PLoS Pathogens

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

(2012) Erin Garrison et al.   PLoS Pathogens

TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells

(2012) James M. McCoy et al.   PLoS Pathogens

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

(2011) David T. Riglar et al.   Cell Host & Microbe

Independent Roles of Apical Membrane Antigen 1 and Rhoptry Neck Proteins during Host Cell Invasion by Apicomplexa

(2011) Donatella Giovannini et al.   Cell Host & Microbe

Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes

(2011) Inga Siden-Kiamos et al.   CELLULAR MICROBIOLOGY

The moving junction of apicomplexan parasites: a key structure for invasion

(2011) Sébastien Besteiro et al.   CELLULAR MICROBIOLOGY

The Malaria Parasite Progressively Dismantles the Host Erythrocyte Cytoskeleton for Efficient Egress

(2011) Melanie G. Millholland et al.   MOLECULAR & CELLULAR PROTEOMICS

Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii

(2011) Simren Mehta et al.   MOLECULAR BIOLOGY OF THE CELL

Binding ofPlasmodiummerozoite proteins RON2 and AMA1 triggers commitment to invasion

(2011) Prakash Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide

(2011) M. L. Tonkin et al.   SCIENCE

The Moving Junction Protein RON8 Facilitates Firm Attachment and Host Cell Invasion in Toxoplasma gondii

(2011) Kurtis W. Straub et al.   PLoS Pathogens

Evolutionarily Divergent, Unstable Filamentous Actin Is Essential for Gliding Motility in Apicomplexan Parasites

(2011) Kristen M. Skillman et al.   PLoS Pathogens

Quantitative in vivo Analyses Reveal Calcium-dependent Phosphorylation Sites and Identifies a Novel Component of the Toxoplasma Invasion Motor Complex

(2011) Thomas Nebl et al.   PLoS Pathogens

The Motility of a Human Parasite, Toxoplasma gondii, Is Regulated by a Novel Lysine Methyltransferase

(2011) Aoife T. Heaslip et al.   PLoS Pathogens

The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites

(2011) Mauld Lamarque et al.   PLoS Pathogens

The C-Terminus of Toxoplasma RON2 Provides the Crucial Link between AMA1 and the Host-Associated Invasion Complex

(2011) Jessica S. Tyler et al.   PLoS Pathogens

Functional Dissection of the Apicomplexan Glideosome Molecular Architecture

(2010) Karine Frénal et al.   Cell Host & Microbe

Multistep adhesion of Plasmodium sporozoites

(2010) Stephan Hegge et al.   FASEB JOURNAL

Sialic acids: Key determinants for invasion by the Apicomplexa

(2010) Nikolas Friedrich et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Rhomboid 4 (ROM4) Affects the Processing of Surface Adhesins and Facilitates Host Cell Invasion by Toxoplasma gondii

(2010) Jeffrey S. Buguliskis et al.   PLoS Pathogens

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

A Small-Molecule Inhibitor of T. gondii Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor Activity

(2010) Aoife T. Heaslip et al.   PLoS Pathogens

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

Concerted Action of Two Formins in Gliding Motility and Host Cell Invasion by Toxoplasma gondii

(2010) Wassim Daher et al.   PLoS Pathogens

Plasmodium Sporozoite Motility Is Modulated by the Turnover of Discrete Adhesion Sites

(2009) Sylvia Münter et al.   Cell Host & Microbe

Host Cell Entry by Apicomplexa Parasites Requires Actin Polymerization in the Host Cell

(2009) Virginie Gonzalez et al.   Cell Host & Microbe

Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites

(2009) Oliver Billker et al.   Cell Host & Microbe

Aldolase Is Essential for Energy Production and Bridging Adhesin-Actin Cytoskeletal Interactions during Parasite Invasion of Host Cells

(2009) G. Lucas Starnes et al.   Cell Host & Microbe

Toxoplasma gondii Actin Depolymerizing Factor Acts Primarily to Sequester G-actin

(2009) Simren Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role

(2009) Hayley E. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motility of malaria sporozoites

(2009) Markus Ganter et al.   MOLECULAR MICROBIOLOGY

Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells

(2009) R. Chandramohanadas et al.   SCIENCE

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

(2009) Moritz Treeck et al.   PLoS Pathogens

Export of a Toxoplasma gondii Rhoptry Neck Protein Complex at the Host Cell Membrane to Form the Moving Junction during Invasion

(2009) Sébastien Besteiro et al.   PLoS Pathogens

A Malaria Parasite Formin Regulates Actin Polymerization and Localizes to the Parasite-Erythrocyte Moving Junction during Invasion

(2008) Jake Baum et al.   Cell Host & Microbe

Toxoplasma Profilin Is Essential for Host Cell Invasion and TLR11-Dependent Induction of an Interleukin-12 Response

(2008) Fabienne Plattner et al.   Cell Host & Microbe

Novel components of the Apicomplexan moving junction reveal conserved and coccidia-restricted elements

(2008) Kurtis W. Straub et al.   CELLULAR MICROBIOLOGY

Role for thePlasmodiumsporozoite-specific transmembrane protein S6 in parasite motility and efficient malaria transmission

(2008) Marion Steinbuechel et al.   CELLULAR MICROBIOLOGY

Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites

(2008) Paul R. Gilson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Microneme protein 8 - a new essential invasion factor in Toxoplasma gondii

(2008) H. Kessler et al.   JOURNAL OF CELL SCIENCE

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

(2008) B. F. C. Kafsack et al.   SCIENCE

Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma

(2008) Jake Baum et al.   TRENDS IN PARASITOLOGY