Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives

Alterations in ruminal bacterial populations at induction and recovery from diet-induced milk fat depression in dairy cows

(2018) D.W. Pitta et al.   JOURNAL OF DAIRY SCIENCE

Time-dependent effect of trans -10, cis -12 conjugated linoleic acid on gene expression of lipogenic enzymes and regulators in mammary tissue of dairy cows

(2018) Kevin J. Harvatine et al.   JOURNAL OF DAIRY SCIENCE

Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota

(2018) Laura J den Hartigh et al.   JOURNAL OF NUTRITION

In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation

(2018) Luis Villacorta et al.   Redox Biology

A Diet Rich in Conjugated Linoleic Acid and Butter Increases Lipid Peroxidation but Does Not Affect Atherosclerotic, Inflammatory, or Diabetic Risk Markers in Healthy Young Men

(2018) Marianne Raff et al.   JOURNAL OF NUTRITION

Conjugated Linoleic Acid Reduces Body Fat Accretion and Lipogenic Gene Expression in Neonatal Pigs Fed Low- or High-Fat Formulas

(2018) Benjamin A. Corl et al.   JOURNAL OF NUTRITION

Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand-Dependent PPARγ Activity in Primary Cultures of Human Adipocytes

(2018) Arion Kennedy et al.   JOURNAL OF NUTRITION

10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against Atherosclerosis in Mice and Is Associated with Alternative Macrophage Enrichment in Perivascular Adipose Tissue

(2018) Jenny Kanter et al.   Nutrients

Rosiglitazone Improves Insulin Resistance Mediated by 10,12 Conjugated Linoleic Acid in a Male Mouse Model of Metabolic Syndrome

(2017) Shari Wang et al.   ENDOCRINOLOGY

Milk from cows grazing on cool-season pastures provides an enhanced profile of bioactive fatty acids compared to those grazed on a monoculture of pearl millet

(2017) Melissa L. Bainbridge et al.   FOOD CHEMISTRY

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Can we improve the nutritional quality of meat?

(2017) Nigel D. Scollan et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice

(2017) Laura J. den Hartigh et al.   PLoS One

Effect of Conjugated Linoleic Acid Associated with Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-Blinded, and Placebo-Controlled Trial

(2016) Alex S. Ribeiro et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in obese children: Randomized Clinical Trial

(2016) NAYELY GARIBAY-NIETO et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women

(2016) Monika Dus-Zuchowska et al.   Food & Nutrition Research

M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis

(2016) Monica de Gaetano et al.   Frontiers in Immunology

Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice

(2015) Tatiana M. Marques et al.   BRITISH JOURNAL OF NUTRITION

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

(2015) Meghan Delmastro-Greenwood et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genes

(2015) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation

(2015) Monica de Gaetano et al.   Journal of Inflammation-London

Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice

(2015) Wan Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial

(2015) Eva-Maria Bachmair et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine

(2015) Jianglin Fan et al.   PHARMACOLOGY & THERAPEUTICS

Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid

(2014) Flavia Baraldi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gut Microbial Metabolites of Polyunsaturated Fatty Acids Correlate with Specific Fecal Bacteria and Serum Markers of Metabolic Syndrome in Obese Women

(2014) Céline Druart et al.   LIPIDS

Role of the Lower and Upper Intestine in the Production and Absorption of Gut Microbiota-Derived PUFA Metabolites

(2014) Céline Druart et al.   PLoS One

Dietary Conjugated Linoleic Acid Supplementation Leads to Downregulation of PPAR Transcription in Broiler Chickens and Reduction of Adipocyte Cellularity

(2014) Suriya Kumari Ramiah et al.   PPAR Research

Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress

(2013) Anne-Sophie Pierre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue

(2013) Margit M. McGowan et al.   BREAST CANCER RESEARCH AND TREATMENT

Conjugated Linoleic Acid Targets  2 Integrin Expression To Suppress Monocyte Adhesion

(2013) M. de Gaetano et al.   JOURNAL OF IMMUNOLOGY

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species

(2013) Laura J. den Hartigh et al.   JOURNAL OF LIPID RESEARCH

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine

(2013) Sonia R. Salvatore et al.   JOURNAL OF LIPID RESEARCH

Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice

(2013) Wan Shen et al.   JOURNAL OF LIPID RESEARCH

Milk Enriched with Conjugated Linoleic Acid Fails to Alter Blood Lipids or Body Composition in Moderately Overweight, Borderline Hyperlipidemic Individuals

(2013) Sudha Venkatramanan et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

CLA Does Not Impair Endothelial Function and Decreases Body Weight as Compared with Safflower Oil in Overweight and Obese Male Subjects

(2013) Maria Pfeuffer et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Anti-inflammatory and anti-atherogenic properties of adiponectin

(2012) Koji Ohashi et al.   BIOCHIMIE

Effects of conjugated linoleic acid supplementation and exercise on post-heparin lipoprotein lipase, butyrylcholinesterase, blood lipid profile and glucose metabolism in young men

(2012) Suleyman Bulut et al.   CHEMICO-BIOLOGICAL INTERACTIONS

IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis

(2012) Cathal McCarthy et al.   FASEB JOURNAL

Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration

(2012) Gustavo Bonacci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Conjugated Linoleic Acid Activates PPARγ and the Intestinal Trefoil Factor in SW480 Cells and Mice with Dextran Sulfate Sodium-Induced Colitis

(2012) Sara Borniquel et al.   JOURNAL OF NUTRITION

trans-10,cis-12 Conjugated Linoleic Acid Enhances Endurance Capacity by Increasing Fatty Acid Oxidation and Reducing Glycogen Utilization in Mice

(2012) Jun Ho Kim et al.   LIPIDS

Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population

(2012) Shu-Chiun Chen et al.   NUTRITION

t-10, c-12 CLA Dietary Supplementation Inhibits Atherosclerotic Lesion Development Despite Adverse Cardiovascular and Hepatic Metabolic Marker Profiles

(2012) Patricia L. Mitchell et al.   PLoS One

As yet uncultured bacteria phylogenetically classified asPrevotella,Lachnospiraceaeincertae sedis and unclassifiedBacteroidales,ClostridialesandRuminococcaceaemay play a predominant role in ruminal biohydrogenation

(2011) Sharon A. Huws et al.   ENVIRONMENTAL MICROBIOLOGY

Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies

(2011) N T Bendsen et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid

(2011) Eileen F. O'Shea et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface

(2011) Ewa Stachowska et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Conjugated Linoleic Acid Supplementation for 8 Weeks Does Not Affect Body Composition, Lipid Profile, or Safety Biomarkers in Overweight, Hyperlipidemic Men

(2011) Shama V. Joseph et al.   JOURNAL OF NUTRITION

Biohydrogenation of Linolenic Acid to Stearic Acid by the Rumen Microbial Population Yields Multiple Intermediate Conjugated Diene Isomers

(2011) Yong-Jae Lee et al.   JOURNAL OF NUTRITION

Effects of margarine supplemented with T10C12 and C9T11 CLA on atherosclerosis and steatosis in apoE/LDLR -/- mice

(2011) Renata B. Kostogrys et al.   Journal of Nutrition Health & Aging

Effect of conjugated linoleic acid on body fat accretion in overweight or obese children

(2010) Natalie M Racine et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The role of microbes in rumen lipolysis and biohydrogenation and their manipulation

(2010) M. Lourenço et al.   Animal

Production of conjugated linoleic acid and conjugated linolenic acid isomers by Bifidobacterium species

(2010) Lara Gorissen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell

(2010) Sarah McClelland et al.   ATHEROSCLEROSIS

Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens

(2010) Margarida RG Maia et al.   BMC MICROBIOLOGY

Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice

(2010) Margaret Flowers et al.   CARCINOGENESIS

Polyunsaturated Fatty Acids and Modulation of Cholesterol Homeostasis in THP-1 Macrophage-Derived Foam Cells

(2010) Masoud Salehipour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative Study of High-Linoleic Acid Vegetable Oils for the Production of Conjugated Linoleic Acid

(2010) Whitney Gammill et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow

(2010) Ryosuke Shiraishi et al.   JOURNAL OF GASTROENTEROLOGY

Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPARγ

(2010) Nicholas P. Evans et al.   JOURNAL OF NUTRITION

Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high-fat diet

(2010) Pilar Parra et al.   Nutrition & Metabolism

A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef

(2010) Cynthia A Daley et al.   Nutrition Journal

Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus

(2009) Leigh E Norris et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults

(2009) Ivonne Sluijs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

9E,11E-Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-1 Receptor Antagonist, in RAW 264.7 Cells

(2009) Yunkyoung Lee et al.   JOURNAL OF NUTRITION

Conjugated Linoleic Acids Reduce Body Fat in Healthy Postmenopausal Women

(2009) Marianne Raff et al.   JOURNAL OF NUTRITION

Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice

(2009) Ganesh V. Halade et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Conjugated Linoleic Acid Induces Uncoupling Protein 1 in White Adipose Tissue of ob/ob Mice

(2009) Angela A. Wendel et al.   LIPIDS

Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE−/− mice fed a high-cholesterol diet

(2008) Margaret H. Cooper et al.   ATHEROSCLEROSIS

t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways

(2008) Xiaojing Meng et al.   CARCINOGENESIS

Conjugated linoleic acids differentially alter polyp number and diameter in the Apcmin/+mouse model of intestinal cancer

(2008) N. Mandir et al.   CELL PROLIFERATION

Dietary conjugated linoleic acid increases PPARγ gene expression in adipose tissue of obese rat, and improves insulin resistance

(2008) Xiao-Rong Zhou et al.   GROWTH HORMONE & IGF RESEARCH

Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7

(2008) Yunkyoung Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antiobesity effect of PEGylated conjugated linoleic acid on high-fat diet-induced obese C57BL/6J (ob/ob) mice: attenuation of insulin resistance and enhancement of antioxidant defenses

(2008) Hyun-Seuk Moon et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Conjugated Linoleic Acid Isomers Reduce Cholesterol Accumulation in Acetylated LDL-Induced Mouse RAW264.7 Macrophage-Derived Foam Cells

(2008) Robert Ringseis et al.   LIPIDS

Effect of a Conjugated Linoleic Acid and ω-3 Fatty Acid Mixture on Body Composition and Adiponectin

(2008) Alan A. Sneddon et al.   Obesity