10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against Atherosclerosis in Mice and Is Associated with Alternative Macrophage Enrichment in Perivascular Adipose Tissue

Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota

(2018) Laura J den Hartigh et al.   JOURNAL OF NUTRITION

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice

(2017) Laura J. den Hartigh et al.   PLoS One

Do theApoe−/−andLdlr−/–Mice Yield the Same Insight on Atherogenesis?Highlights: Table.

(2016) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells

(2016) Edenil C. Aguilar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Microbial metabolite butyrate facilitates M2 macrophage polarization and function

(2016) Jian Ji et al.   Scientific Reports

Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype

(2015) Suguru Yamamoto et al.   ATHEROSCLEROSIS

PCSK9 inhibitors and cardiovascular disease

(2015) M. John Chapman et al.   CURRENT OPINION IN LIPIDOLOGY

Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation

(2015) Monica de Gaetano et al.   Journal of Inflammation-London

Regional differences in perivascular adipose tissue impacting vascular homeostasis

(2015) Marta Gil-Ortega et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

(2015) Florian Willecke et al.   PLoS One

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice

(2014) Laura J. den Hartigh et al.   PLoS One

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species

(2013) Laura J. den Hartigh et al.   JOURNAL OF LIPID RESEARCH

Toll-Like Receptor 4 Deficiency Decreases Atherosclerosis But Does Not Protect Against Inflammation in Obese Low-Density Lipoprotein Receptor–Deficient Mice

(2012) Yilei Ding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

(2012) Lin Chang et al.   CIRCULATION

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

(2012) Larissa Cardilo-Reis et al.   EMBO Molecular Medicine

IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis

(2012) Cathal McCarthy et al.   FASEB JOURNAL

Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation

(2012) Tomio Umemoto et al.   JOURNAL OF LIPID RESEARCH

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

(2012) Jonathan E. Feig et al.   PLoS One

t-10, c-12 CLA Dietary Supplementation Inhibits Atherosclerotic Lesion Development Despite Adverse Cardiovascular and Hepatic Metabolic Marker Profiles

(2012) Patricia L. Mitchell et al.   PLoS One

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Effects of margarine supplemented with T10C12 and C9T11 CLA on atherosclerosis and steatosis in apoE/LDLR -/- mice

(2011) Renata B. Kostogrys et al.   Journal of Nutrition Health & Aging

Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue

(2011) Yoichiro Hirata et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Association between serum amyloid A and obesity: a meta-analysis and systematic review

(2010) Yulan Zhao et al.   INFLAMMATION RESEARCH

Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium

(2009) Yong Woo Lee et al.   CYTOKINE

Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis

(2009) Melissa S. Ashwell et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor–Deficient Mice

(2008) Savitha Subramanian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE−/− mice fed a high-cholesterol diet

(2008) Margaret H. Cooper et al.   ATHEROSCLEROSIS

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark