Ebola Virus Entry: From Molecular Characterization to Drug Discovery

Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein

(2018) Quanjie Li et al.   ANTIVIRAL RESEARCH

Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection

(2018) Olena Shtanko et al.   ANTIVIRAL RESEARCH

Repurposing potential of 1st generation H 1 -specific antihistamines as anti-filovirus therapeutics

(2018) Adam Schafer et al.   ANTIVIRAL RESEARCH

Discovery and evolution of aloperine derivatives as novel anti-filovirus agents through targeting entry stage

(2018) Xin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ebola Virus Transmission Caused by Persistently Infected Survivors of the 2014–2016 Outbreak in West Africa

(2018) Lorenzo Subissi et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

(2018) Julie Dyall et al.   JOURNAL OF INFECTIOUS DISEASES

In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

(2018) Julie Dyall et al.   JOURNAL OF INFECTIOUS DISEASES

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection

(2018) Jingshan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity

(2018) Szu-Yuan Pu et al.   JOURNAL OF MEDICINAL CHEMISTRY

1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features

(2018) Sarah Moeschler et al.   Viruses-Basel

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

(2018) Qinghua Cui et al.   Viruses-Basel

Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors

(2018) Qing Chen et al.   Acta Pharmaceutica Sinica B

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

(2018) Shu Yang et al.   Cell Discovery

High-throughput drug screening using the Ebola virus transcription- and replication-competent virus-like particle system

(2018) Nakyung Lee et al.   ANTIVIRAL RESEARCH

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

(2018) Tracey Goldstein et al.   Nature Microbiology

Phenotypic Prioritization of Diphyllin Derivatives That Block Filoviral Cell Entry by Vacuolar (H+ )-ATPase Inhibition

(2018) Aaron Lindstrom et al.   ChemMedChem

Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus

(2018) Qinghua Cui et al.   Viruses-Basel

Characterization of a filovirus (Měnglà virus) from Rousettus bats in China

(2018) Xing-Lou Yang et al.   Nature Microbiology

Antiviral activity of cationic amphiphilic drugs

(2017) Cristiano Salata et al.   Expert Review of Anti-Infective Therapy

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium

(2017) Hanlu Fan et al.   Scientific Reports

Pseudotyped Lentiviral Vectors: One Vector, Many Guises

(2017) Alok V. Joglekar et al.   Human Gene Therapy Methods

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

(2017) Elizabeth A. Nelson et al.   PLoS Neglected Tropical Diseases

Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors

(2016) Manu Anantpadma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library

(2016) Simon Beck et al.   ANTIVIRAL RESEARCH

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry

(2016) Baptiste Martin et al.   ANTIVIRAL RESEARCH

Teicoplanin inhibits Ebola pseudovirus infection in cell culture

(2016) Yizhuo Wang et al.   ANTIVIRAL RESEARCH

Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity

(2016) Hephzibah Akpovwa   CELL BIOCHEMISTRY AND FUNCTION

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

(2016) Nan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives

(2016) José Eduardo Vargas et al.   Journal of Translational Medicine

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

(2016) Yuguang Zhao et al.   NATURE

Effect of Artesunate–Amodiaquine on Mortality Related to Ebola Virus Disease

(2016) Etienne Gignoux et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry

(2016) Lisa Henß et al.   Virology Journal

Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications

(2016) Elizabeth Nelson et al.   Viruses-Basel

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

(2016) Zachary A. Bornholdt et al.   mBio

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

(2016) Wouter A. van der Linden et al.   ACS Infectious Diseases

Blood kinetics of Ebola virus in survivors and nonsurvivors

(2015) Simone Lanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model

(2015) Stuart D. Dowall et al.   JOURNAL OF GENERAL VIROLOGY

Novel Small Molecule Entry Inhibitors of Ebola Virus

(2015) Arnab Basu et al.   JOURNAL OF INFECTIOUS DISEASES

Ebolavirus Glycoprotein Directs Fusion through NPC1 + Endolysosomes

(2015) James A. Simmons et al.   JOURNAL OF VIROLOGY

Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists

(2015) Han Cheng et al.   JOURNAL OF VIROLOGY

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

(2015) Timo Wolf et al.   LANCET

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Combating emerging viral threats

(2015) E. Bekerman et al.   SCIENCE

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

(2015) Lisa M. Johansen et al.   Science Translational Medicine

Phenothiazine-Derived Antipsychotic Drugs Inhibit Dynamin and Clathrin-Mediated Endocytosis

(2015) James A. Daniel et al.   TRAFFIC

Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process

(2015) Cristiano Salata et al.   Pathogens and Disease

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

(2015) Peter B. Madrid et al.   ACS Infectious Diseases

Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells

(2014) Joshua C. Johnson et al.   ANTIVIRAL RESEARCH

Reverse genetics systems as tools for the development of novel therapies against filoviruses

(2014) Thomas Hoenen et al.   Expert Review of Anti-Infective Therapy

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel Life Cycle Modeling System for Ebola Virus Shows a Genome Length-Dependent Role of VP24 in Virus Infectivity

(2014) A. Watt et al.   JOURNAL OF VIROLOGY

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

(2014) Jennifer Kouznetsova et al.   Emerging Microbes & Infections

Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle

(2013) Zachary A. Bornholdt et al.   CELL

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors

(2013) Matthew Brudner et al.   PLoS One

Correction: Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection

(2013) Charles J. Shoemaker et al.   PLoS One

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

Ebolavirus Requires Acid Sphingomyelinase Activity and Plasma Membrane Sphingomyelin for Infection

(2012) M. E. Miller et al.   JOURNAL OF VIROLOGY

A new player in the puzzle of filovirus entry

(2012) Judith M. White et al.   NATURE REVIEWS MICROBIOLOGY

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase

(2012) M. Garcia et al.   Science Translational Medicine

Minigenomes, transcription and replication competent virus-like particles and beyond: Reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses

(2011) Thomas Hoenen et al.   ANTIVIRAL RESEARCH

Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin

(2011) Katsuaki Usami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes

(2011) Emily Happy Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Proline-Rich Region of Ebola Virus Matrix Protein VP40 Is Essential for Plasma Membrane Targeting and Virus-Like Particle Release

(2011) Olivier Reynard et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Vesicular Stomatitis Virus–Based Vaccines Against Ebola and Marburg Virus Infections

(2011) Thomas W. Geisbert et al.   JOURNAL OF INFECTIOUS DISEASES

Cathepsin Cleavage Potentiates the Ebola Virus Glycoprotein To Undergo a Subsequent Fusion-Relevant Conformational Change

(2011) M. Brecher et al.   JOURNAL OF VIROLOGY

Identification of a Small-Molecule Entry Inhibitor for Filoviruses

(2011) A. Basu et al.   JOURNAL OF VIROLOGY

Use of chloroquine in viral diseases

(2011) Andrea Savarino   LANCET INFECTIOUS DISEASES

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein

(2011) Melinda A. Brindley et al.   VIROLOGY

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

(2011) Nirupama Mulherkar et al.   VIROLOGY

Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines

(2010) Michael A. Whitt   JOURNAL OF VIROLOGICAL METHODS

Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

(2010) C. L. Hood et al.   JOURNAL OF VIROLOGY

The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus

(2010) C. L. Hunt et al.   JOURNAL OF VIROLOGY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Ebola virus uses clathrin-mediated endocytosis as an entry pathway

(2010) Suchita Bhattacharyya et al.   VIROLOGY

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition

(2009) Osvaldo Martinez et al.   CELLULAR MICROBIOLOGY

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

An enzymatic virus-like particle assay for sensitive detection of virus entry

(2009) Donna M. Tscherne et al.   JOURNAL OF VIROLOGICAL METHODS

The Primed Ebolavirus Glycoprotein (19-Kilodalton GP1,2): Sequence and Residues Critical for Host Cell Binding

(2009) D. Dube et al.   JOURNAL OF VIROLOGY

 5 1-Integrin controls ebolavirus entry by regulating endosomal cathepsins

(2009) K. L. Schornberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE