A new player in the puzzle of filovirus entry

Virus entry: old viruses, new receptors

(2012) Marija Backovic et al.   Current Opinion in Virology

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Membrane dynamics and fusion at late endosomes and vacuoles – Rab regulation, multisubunit tethering complexes and SNAREs

(2011) Nadine Epp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Reston ebolavirus in Humans and Animals in the Philippines: A Review

(2011) Mary Elizabeth G. Miranda et al.   JOURNAL OF INFECTIOUS DISEASES

Cathepsin Cleavage Potentiates the Ebola Virus Glycoprotein To Undergo a Subsequent Fusion-Relevant Conformational Change

(2011) M. Brecher et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

A shared structural solution for neutralizing ebolaviruses

(2011) João M Dias et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2

(2011) S. M. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

(2011) M. S. Deffieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein

(2011) Melinda A. Brindley et al.   VIROLOGY

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

(2011) Nirupama Mulherkar et al.   VIROLOGY

Late-penetrating viruses

(2011) Pierre-Yves Lozach et al.   Current Opinion in Virology

Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells

(2011) Tanmay A. M. Bharat et al.   PLOS BIOLOGY

Discovery of an Ebolavirus-Like Filovirus in Europe

(2011) Ana Negredo et al.   PLoS Pathogens

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

(2010) Jens H. Kuhn et al.   ARCHIVES OF VIROLOGY

C-type lectins do not act as functional receptors for filovirus entry into cells

(2010) Keita Matsuno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases

(2010) Einat B. Vitner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

(2010) C. L. Hood et al.   JOURNAL OF VIROLOGY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy

(2010) Elodie Teissier et al.   MOLECULES

Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry

(2010) D. Dube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

(2010) Emyr Lloyd-Evans et al.   TRAFFIC

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Entry inhibitors in the treatment of HIV-1 infection

(2009) John C. Tilton et al.   ANTIVIRAL RESEARCH

Delivery of endocytosed membrane proteins to the lysosome

(2009) Paul R. Pryor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry

(2009) A. C. Wong et al.   JOURNAL OF VIROLOGY

The Primed Ebolavirus Glycoprotein (19-Kilodalton GP1,2): Sequence and Residues Critical for Host Cell Binding

(2009) D. Dube et al.   JOURNAL OF VIROLOGY

Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

(2009) Nancy J. Sullivan et al.   NATURE REVIEWS MICROBIOLOGY

 5 1-Integrin controls ebolavirus entry by regulating endosomal cathepsins

(2009) K. L. Schornberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

(2008) Judith M. White et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Characterization of Fluorescent Sterol Binding to Purified Human NPC1

(2008) Ronghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY