Article
Cell Biology
Chong Gao, Meiling Wu, Qiaohui Du, Jiagang Deng, Jiangang Shen
Summary: This study found that naringin promotes adult hippocampal neurogenesis and improves depression-like behaviors by regulating the BDNF/TrkB/CREB signaling pathway. The results showed that naringin enhances the proliferation of neural stem/progenitor cells and accelerates neuronal differentiation, and its antidepressant and anxiolytic effects are attributed to enhanced hippocampal neurogenesis via activating CREB signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Yingying Jiang, Qingying Liu, Yumei Zhao, Chunyang Wang, Ming Sun
Summary: Cerebral ischemia leads to excitotoxicity and neural apoptosis. In this study, the effects of chemogenetic inhibition or activation of glutamatergic neurons in the vCA1 region on sequelae induced by cerebral ischemia were investigated. The results showed that inhibition of vCA1 pyramidal neurons alleviated neurological deficits, pain perception, anxiety, and depression, while activation had limited effects. Additionally, overexpression of CREB protein in vCA1 pyramidal neurons improved the dysfunction induced by ischemic stroke by upregulating BDNF.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Summary: In a mouse study, low-dose curcumin was found to promote hippocampal neurogenesis and enhance memory retention, suggesting its potential role in preventing age and neurodegenerative disease-related cognitive deficits.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Neurosciences
Sihan Guo, Ruimin Wang, Jiewei Hu, Liping Sun, Xinru Zhao, Yufeng Zhao, Dong Han, Shuqun Hu
Summary: The study found that PBM treatment had a significant neuroprotective effect and improved spatial learning and memory ability at 58 days post-ischemia. Mechanistic studies showed that PBM suppressed reactive astrocytes and increased neurogenesis, contributing to neurological recovery after GCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Singh
Summary: This study investigated the effects of heat stress on the hippocampus and spatial memory in rats, revealing that heat exposure can lead to oxidative damage, neuronal apoptosis and spatial memory deficits in the hippocampus. Furthermore, the dysregulation of the BDNF/ERK1/2/CREB axis was found to be associated with cognitive decline under heat stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Haiyan Li, Sijie Li, Changhong Ren, Chen Gao, Ning Li, Chunxiu Wang, Lin Wang, Wenbo Zhao, Xunming Ji, Kunlin Jin
Summary: This study found that hypoxic postconditioning (HPC) helps promote neurogenesis after ischemic stroke, increasing the proliferation and migration of neural stem cells. HPC also regulates the metabolism of neural stem cells, including reducing fatty acid oxidation and increasing glycolysis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Behavioral Sciences
Bin Feng, Sansan Jia, Liya Li, Jiajia Wang, Fang Zhou, Xingchun Gou, Qiang Wang, Lize Xiong, Yi Zeng, Haixing Zhong
Summary: This study found that TAT-LBD-Ngn2 could significantly improve long-term learning and memory by promoting neurogenesis in the hippocampus, suggesting it may be an appealing candidate for treating poststroke neurocognitive disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Immunology
Yunong Li, Jiaolin Zheng, Yanmei Zhu, Youyang Qu, Rui Suo, Yulan Zhu
Summary: Methylcobalamin demonstrates neuroprotective effects on cerebral ischemic injury by increasing cell viability and autophagy, reducing inflammation and apoptosis, and activating the ERK1/2 pathway. Its potential as a novel neuroprotective therapy for ischemic stroke is promising.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rong Ma, Qian Xie, Hongyan Li, Xiaoqing Guo, Jian Wang, Yong Li, Mihong Ren, Daoyin Gong, Tian Gao
Summary: L-borneol can improve neurological deficits, reduce cerebral infarction, and promote angiogenesis by increasing levels of Ang-1 and VEGF, while also promoting neurogenesis, as well as affecting the expression of VEGF, BDNF, TGF-beta 1, and MMP9 to play a neuroprotective role in cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Wei-Wei Wang, Xiao-Lei Liu, Yu Ding, Ya-Di Chen, Dan Ma, Rui Bu, Tian-Hao Bao
Summary: This study investigated the protective effects of Scutellarin on myocardial ischemia-reperfusion injury and found that it reduced the size of myocardial infarctions and decreased levels of injury markers. Scutellarin also regulated mitophagy, reduced oxidative stress, stabilized mitochondrial function, and increased cell viability. This study highlights the potential of Scutellarin as a therapeutic agent for myocardial injury.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Endocrinology & Metabolism
Congying Chen, Lingling Bu, Huan Liu, Yifeng Rang, Huiying Huang, Xueman Xiao, Genghua Ou, Chunhong Liu
Summary: This study found that 1,4-butanediol induces oxidative stress and inflammation in PC12 cells, leading to reduced levels of Glutathione and Acetylcholine, and ultimately resulting in learning and memory impairment. Furthermore, 1,4-butanediol affects synaptic plasticity via the ERK1/2-CREB-BDNF pathway.
METABOLIC BRAIN DISEASE
(2022)
Review
Clinical Neurology
Jiale Gao, Mingjiang Yao, Dennis Chang, Jianxun Liu
Summary: Ischemic stroke is a leading cause of morbidity and disability globally. The body's limited repair capacity makes the sequelae of serious neurological damage irreversible. However, endogenous neurogenesis induced by cerebral ischemia plays a critical role in the repair and regeneration of impaired neural cells after ischemic brain injury.
Article
Biochemistry & Molecular Biology
Musadiq A. Bhat, Thomas Grampp, Dietmar Benke
Summary: The downregulation of GABA(B) receptors is associated with neurological diseases, and CaMKII beta and ERK1/2 are involved in this process through phosphorylation of S867 and T872 in GABA(B1) subunit. Blocking ERK activity can restore the expression of GABA(B) receptors after ischemic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Immunology
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Summary: Depressed mice have lower numbers of microglia in the dentate gyrus. Reversing this decline with a single low dose of lipopolysaccharide has antidepressant effects. The antidepressant effect is related to the synthesis and signaling pathway of brain-derived neurotrophic factor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)