Biologically Active Macrocyclic Compounds - from Natural Products to Diversity-Oriented Synthesis

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

(2010) John A. McCauley et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules

(2010) Ryan Hili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a General, Sequential, Ring-Closing Metathesis/Intramolecular Cross-Coupling Reaction for the Synthesis of Polyunsaturated Macrolactones

(2010) Scott E. Denmark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of new diverse macrocycles from diol precursors

(2010) Charlotte M. Madsen et al.   TETRAHEDRON

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

(2009) T.-I Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiple Multicomponent Macrocyclizations (MiBs): A Strategic Development Toward Macrocycle Diversity

(2009) Ludger A. Wessjohann et al.   CHEMICAL REVIEWS

Macrocyclic inhibitors of HCV NS3 protease

(2009) Srikanth Venkatraman et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Accessing Skeletal Diversity Using Catalyst Control: Formation ofnandn+ 1 Macrocyclic Triazole Rings

(2009) Ann Rowley Kelly et al.   ORGANIC LETTERS

Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds

(2008) Daniel Morton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

(2008) S. D. Seiwert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

(2008) Pierre Raboisson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

A Fluorous-Tagged Linker from Which Small Molecules Are Released by Ring-Closing Metathesis

(2008) Stuart G. Leach et al.   JOURNAL OF ORGANIC CHEMISTRY

Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable forin VitroSelection

(2008) Brian N. Tse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis

(2008) Christopher Cordier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs)

(2008) Daniel G. Rivera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams

(2008) Chong Han et al.   ORGANIC LETTERS

Rapid synthesis of macrocycles from diol precursors

(2008) Magnus J. Wingstrand et al.   TETRAHEDRON LETTERS