Towards the systematic exploration of chemical space

Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules

(2011) Sarah Murrison et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues

(2011) Hiroki Oguri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

A Cooperative Participation of the Amido Group in the Organocatalytic Construction of All-Carbon Quaternary Stereocenters by Michael Addition with β-Ketoamides

(2011) Maria del Mar Sanchez Duque et al.   ORGANIC LETTERS

Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

(2011) J. Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library

(2011) G. Moura-Letts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions

(2010) Catherine O'Leary-Steele et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current strategies for diversity-oriented synthesis

(2010) Sivaraman Dandapani et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-based discovery of antibacterial drugs

(2010) Katie J. Simmons et al.   NATURE REVIEWS MICROBIOLOGY

Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy

(2010) Alan Rolfe et al.   ORGANIC LETTERS

A Formal [4 + 4] Complementary Ambiphile Pairing Reaction: A New Cyclization Pathway forortho-Quinone Methides

(2010) Thiwanka B. Samarakoon et al.   ORGANIC LETTERS

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Remarkably Slow Rotation about a Single Bond between an sp3-Hybridised Carbon Atom and an Aromatic Ring withoutorthoSubstituents

(2009) Sarah Murrison et al.   CHEMISTRY-A EUROPEAN JOURNAL

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic Analysis of Public Domain Compound Potency Data Identifies Selective Molecular Scaffolds across Druggable Target Families

(2009) Ye Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Killing 84 birds with one stone

(2009) Herbert Waldmann   Nature Chemical Biology

Bioactivity-guided mapping and navigation of chemical space

(2009) Steffen Renner et al.   Nature Chemical Biology

Interactive exploration of chemical space with Scaffold Hunter

(2009) Stefan Wetzel et al.   Nature Chemical Biology

Quantifying biogenic bias in screening libraries

(2009) Jérôme Hert et al.   Nature Chemical Biology

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

(2009) Takuya Uchida et al.   ORGANIC LETTERS

A Fluorous-Tagged “Safety Catch” Linker for Preparing Heterocycles by Ring-Closing Metathesis

(2009) Catherine O’Leary-Steele et al.   ORGANIC LETTERS

Convergent synthesis of dihydroquinolones from o-aminoarylboronates

(2009) Joachim Horn et al.   TETRAHEDRON

Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds

(2008) Daniel Morton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis

(2008) Gemma L. Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry

(2008) Alan H. Lipkus et al.   JOURNAL OF ORGANIC CHEMISTRY

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

(2008) Christopher Cordier et al.   NATURAL PRODUCT REPORTS

Convergent, Regiospecific Synthesis of Quinolines fromo-Aminophenylboronates

(2008) Joachim Horn et al.   ORGANIC LETTERS

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION