Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 19, Pages 8042-8048Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2011957
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- NIGMS [P50 GM069721]
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An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.
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