Celastrol as a tool for the study of the biological events of metabolic diseases

Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA

(2018) Xue Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

(2018) Shao-Ru Chen et al.   Frontiers in Pharmacology

Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics

(2017) Yiqing Zhou et al.   Molecular BioSystems

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

(2017) Mengjie Hu et al.   MOLECULAR CELL

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

The brain and immune system prompt energy shortage in chronic inflammation and ageing

(2017) Rainer H. Straub   Nature Reviews Rheumatology

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

(2017) Yi Wang et al.   Nature Communications

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

(2016) Jaemin Lee et al.   NATURE MEDICINE

Positive Correlation between Enhanced Expression of TLR4/MyD88/NF-κB with Insulin Resistance in Placentae of Gestational Diabetes Mellitus

(2016) Hui Feng et al.   PLoS One

Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

(2016) Li-ping Han et al.   Journal of Diabetes Research

Hypothalamic Inflammation in the Control of Metabolic Function

(2015) Martin Valdearcos et al.   Annual Review of Physiology

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

(2015) Yan Chen et al.   DIABETES

Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products

(2015) Andrew M. Camelio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artemisinin, a miracle of traditional Chinese medicine

(2015) Ling Yi Kong et al.   NATURAL PRODUCT REPORTS

Physiology and relevance of human adaptive thermogenesis response

(2015) Francesco S. Celi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

(2015) Qian Zhao et al.   Chemical Science

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches

(2014) Fabian Sanchis-Gomar et al.   CURRENT PHARMACEUTICAL DESIGN

NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis

(2014) Haiwen Ni et al.   PLoS One

Tumor Necrosis Factor-α Sensitizes Breast Cancer Cells to Natural Products with Proteasome-Inhibitory Activity Leading to Apoptosis

(2014) Li Lu et al.   PLoS One

Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

(2013) Longjiang Shao et al.   PLoS One

Female Nur77-Deficient Mice Show Increased Susceptibility to Diet-Induced Obesity

(2013) Sonia Perez-Sieira et al.   PLoS One

Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets

(2012) Lada Klaić et al.   ACS Chemical Biology

Mitochondria and endocrine function of adipose tissue

(2012) Gema Medina-Gómez   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression

(2011) Yoonseo Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Remarkable Stereospecific Conjugate Additions to the Hsp90 Inhibitor Celastrol

(2011) Lada Klaić et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

(2009) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons

(2007) Merisa L. Piper et al.   MOLECULAR ENDOCRINOLOGY