Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics

Proteome-wide covalent ligand discovery in native biological systems

(2016) Keriann M. Backus et al.   NATURE

Withaferin A Analogs That Target the AAA+ Chaperone p97

(2015) Shasha Tao et al.   ACS Chemical Biology

Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

(2015) Daniel Abegg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms

(2015) Daniel Medina-Cleghorn et al.   CHEMISTRY & BIOLOGY

The Expanding Landscape of the Thiol Redox Proteome

(2015) Jing Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

(2015) Qian Zhao et al.   Chemical Science

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target identification of biologically active small molecules via in situ methods

(2013) Ying Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets

(2012) Lada Klaić et al.   ACS Chemical Biology

Glutathione Transferases as Targets for Cancer Therapy

(2012) Paolo Ruzza et al.   Anti-Cancer Agents in Medicinal Chemistry

Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling

(2012) Yongsheng Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90

(2012) Wen-Bo Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gambogic Acid Deactivates Cytosolic and Mitochondrial Thioredoxins by Covalent Binding to the Functional Domain

(2012) Jing Yang et al.   JOURNAL OF NATURAL PRODUCTS

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Identification and validation of protein targets of bioactive small molecules

(2011) Denis V. Titov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells

(2011) Tuomas Paimela et al.   PHARMACOLOGICAL RESEARCH

Quantitative Proteomics Reveals Cellular Targets of Celastrol

(2011) Jakob Hansen et al.   PLoS One

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Cysteine-Based Redox Switches in Enzymes

(2010) Chananat Klomsiri et al.   ANTIOXIDANTS & REDOX SIGNALING

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Chemical ‘omics’ approaches for understanding protein cysteine oxidation in biology

(2010) Stephen E Leonard et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

(2009) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Celastrol Inhibits Hsp90 Chaperoning of Steroid Receptors by Inducing Fibrillization of the Co-chaperone p23

(2009) Ahmed Chadli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Nitrosothiol Reactivity Profiling Identifies S-Nitrosylated Proteins with Unexpected Stability

(2008) Jeremy S. Paige et al.   CHEMISTRY & BIOLOGY

Expanding the functional diversity of proteins through cysteine oxidation

(2008) Khalilah G Reddie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

(2008) Amy Trott et al.   MOLECULAR BIOLOGY OF THE CELL

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS