Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study

Abstract LB-406: Phase 1 study of the Smac mimetic TL32711 in adult subjects with advanced solid tumors and lymphoma to evaluate safety, pharmacokinetics, pharmacodynamics, and antitumor activity

(2014) R. K. Amaravadi et al.   CANCER RESEARCH

Degradation of cIAPs contributes to hepatocyte lipoapoptosis

(2013) Yuko Akazawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer

(2013) Tao Zhang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

IAP proteins as targets for drug development in oncology

(2013) Laurence Dubrez et al.   OncoTargets and Therapy

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer

(2012) Melissa K. Brunckhorst et al.   CANCER BIOLOGY & THERAPY

Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 Is Linked to TNF-α Pharmacology

(2012) Rebecca I. Erickson et al.   TOXICOLOGICAL SCIENCES

Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis

(2012) Harvey Wong et al.   TOXICOLOGICAL SCIENCES

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer

(2011) Koh Miura et al.   SURGERY TODAY

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

(2010) Stig Linder et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER