In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection

Romidepsin reverses HIV-1 latency in vivo

(2016) Kristin Nicole Harper   AIDS

The potential role for romidepsin as a component in early HIV-1 curative efforts

(2016) Jesper Damsgaard Gunst et al.   Expert Review of Anti-Infective Therapy

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

(2015) Gregory Q. Del Prete et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection

(2015) Olivia D. Council et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ex VivoBioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4+T Cells from Aviremic Patients

(2015) Adam M. Spivak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells

(2015) Julia A.M. Sung et al.   JOURNAL OF CLINICAL INVESTIGATION

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

(2015) Rikke Olesen et al.   JOURNAL OF VIROLOGY

In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activation and CD4+ T cell loss

(2015) Richard L Watkins et al.   Retrovirology

Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1

(2015) Marta Martínez-Bonet et al.   Scientific Reports

BLT humanized mice as a small animal model of HIV infection

(2015) Marshall E Karpel et al.   Current Opinion in Virology

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

(2015) Martina Kovarova et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Is it time to abandon single intervention cure trials?

(2015) Jintanat Ananworanich et al.   Lancet HIV

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1

(2015) Daniel I. S. Rosenbloom et al.   Open Forum Infectious Diseases

HDAC inhibitors and immunotherapy; a double edged sword?

(2015) Michiel Kroesen et al.   Oncotarget

Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques

(2014) Gregory Q. Del Prete et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

(2014) N. M. Archin et al.   JOURNAL OF INFECTIOUS DISEASES

Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection

(2014) Fuqin Zhang et al.   MOLECULAR THERAPY

Effects of Treatment with Suppressive Combination Antiretroviral Drug Therapy and the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid; (SAHA) on SIV-Infected Chinese Rhesus Macaques

(2014) Binhua Ling et al.   PLoS One

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

(2014) Paul W. Denton et al.   PLoS Pathogens

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells

(2014) Dominique N Lisiero et al.   Journal for ImmunoTherapy of Cancer

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

(2013) Fiona Wightman et al.   AIDS

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells

(2013) Liang Shan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice

(2013) Morgan L. Chateau et al.   PLoS One

In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

(2013) Richard L Watkins et al.   Retrovirology

Comparison of HDAC inhibitors in clinical development

(2013) Thomas Aagaard Rasmussen et al.   Human Vaccines & Immunotherapeutics

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice

(2012) B. R. Long et al.   JOURNAL OF VIROLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice

(2012) Angela Wahl et al.   PLoS Pathogens

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Targeted cytotoxic therapy: adapting a rapidly progressing anticancer paradigm for depletion of persistent HIV-infected cell reservoirs

(2010) Edward A Berger   Current Opinion in HIV and AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

(2008) Nancy M Archin et al.   AIDS

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE