Hypoxia-inducible factor 1-alpha (HIF-1α) as a factor mediating the relationship between obesity and heart failure with preserved ejection fraction

Neotuberostemonine inhibits the differentiation of lung fibroblasts into myofibroblasts in mice by regulating HIF-1α signaling

(2018) Xin-miao Lv et al.   ACTA PHARMACOLOGICA SINICA

Metabolic Syndrome Is Associated With Impaired Diastolic Function Independently of MRI-Derived Myocardial Extracellular Volume: The MESA Study

(2018) Ricardo Ladeiras-Lopes et al.   DIABETES

Do sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis

(2018) Milton Packer   DIABETES OBESITY & METABOLISM

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Potential impact of SGLT2 inhibitors on left ventricular diastolic function in patients with diabetes mellitus

(2018) Hidekazu Tanaka et al.   HEART FAILURE REVIEWS

Obesity-Related Heart Failure With a Preserved Ejection Fraction

(2018) Milton Packer et al.   JACC-Heart Failure

The functional interplay between the HIF pathway and the ubiquitin system – more than a one-way road

(2017) Julia Günter et al.   EXPERIMENTAL CELL RESEARCH

Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis

(2017) Sean Lee Zheng et al.   HEART

Differences in Gene Expression and Gene Associations in Epicardial Fat Compared to Subcutaneous Fat

(2017) J. Yim et al.   HORMONE AND METABOLIC RESEARCH

The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases

(2017) Hajime Abe et al.   Journal of Atherosclerosis and Thrombosis

Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients

(2017) Cho-Kai Wu et al.   Journal of Clinical Lipidology

Abdominal Obesity Is Associated With an Increased Risk of All-Cause Mortality in Patients With HFpEF

(2017) Tetsuro Tsujimoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

(2017) Gavin A. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Wpływ grubości nasierdziowej tkanki tłuszczowej na czynność rozkurczową lewej komory u chorych z prawidłowymi tętnicami wieńcowymi

(2017) Mustafa Topuz et al.   Kardiologia Polska

Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate

(2017) Reza Norouzirad et al.   Oxidative Medicine and Cellular Longevity

Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis

(2017) Anji Xiong et al.   Frontiers in Pharmacology

Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia

(2017) Bence M. Nagy et al.   Frontiers in Physiology

Age-dependent obesity and mitochondrial dysfunction

(2017) Qilong Oscar Yang Li et al.   Adipocyte

The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue

(2016) Xiaole Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome

(2016) Hiroaki Kusaka et al.   Cardiovascular Diabetology

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

(2016) José J. Fuster et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Pro-resolving mediators produced from EPA and DHA: Overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases

(2016) Cristina López-Vicario et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Relaxin-2 improves diastolic function of pressure-overloaded rats via phospholamban by activating Akt

(2016) Xin-xin Shuai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis

(2016) Jonathan C. Jun et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Functional Status, Pulmonary Artery Pressure, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction

(2016) Daniel Dalos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

(2016) Bethany Baumann et al.   KIDNEY INTERNATIONAL

STEAP4 and HIF-1α gene expressions in visceral and subcutaneous adipose tissue of the morbidly obese patients

(2016) Fusun Ozmen et al.   MOLECULAR IMMUNOLOGY

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

(2016) Talita Antunes Guimarães et al.   Oncotarget

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

The relationship between arterial stiffness and heart failure with preserved ejection fraction: a systemic meta-analysis

(2015) Bryan Chow et al.   HEART FAILURE REVIEWS

Association of systemic inflammation with epicardial fat and coronary artery calcification

(2015) Sören Gauss et al.   INFLAMMATION RESEARCH

Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction

(2015) Xizhong Sui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

(2015) Julie A. Eclov et al.   JOURNAL OF LIPID RESEARCH

Heart failure with preserved ejection fraction in the elderly: scope of the problem

(2015) Bharathi Upadhya et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

(2015) SHENG-LI YANG et al.   Molecular Medicine Reports

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of reducing epicardial fat by exercise, diet or bariatric surgery weight loss strategies: a systematic review and meta-analysis

(2015) S. W. Rabkin et al.   Obesity Reviews

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

(2015) Leyre Martínez-Fernández et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

(2015) Xinke Zhou et al.   Oncotarget

Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies

(2015) Zhila Maghbooli et al.   Biomed Research International

Preclinical Left Ventricular Diastolic Dysfunction in Metabolic Syndrome

(2014) Nir Ayalon et al.   AMERICAN JOURNAL OF CARDIOLOGY

Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients

(2014) Zi-Hui Tang et al.   BMC Cardiovascular Disorders

Association of epicardial fat with left ventricular diastolic function in subjects with metabolic syndrome: assessment using 2-dimensional echocardiography

(2014) Hyo Eun Park et al.   BMC Cardiovascular Disorders

METformin in DIastolic Dysfunction of MEtabolic Syndrome (MET-DIME) Trial: Rationale and Study Design

(2014) Ricardo Ladeiras-Lopes et al.   CARDIOVASCULAR DRUGS AND THERAPY

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration

(2014) Jalahalli M. Siddesha et al.   CELLULAR SIGNALLING

Relationship of Epicardial Fat Thickness with Endothelial and Cardiac Functions in Children with Family History of Type 2 Diabetes Mellitus

(2014) Ragab A. Mahfouz et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

(2014) Romain Eschalier et al.   HYPERTENSION

Relation of epicardial fat to central aortic pressure and left ventricular diastolic function in patients with known or suspected coronary artery disease

(2014) Kenta Hachiya et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1

(2014) Robin J Ruthenborg et al.   MOLECULES AND CELLS

Epicardial fat, rather than pericardial fat, is independently associated with diastolic filling in subjects without apparent heart disease

(2014) S. Dabbah et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Sitagliptin Reduces Cardiac Apoptosis, Hypertrophy and Fibrosis Primarily by Insulin-Dependent Mechanisms in Experimental type-II Diabetes. Potential Roles of GLP-1 Isoforms

(2014) Belén Picatoste et al.   PLoS One

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

(2014) Michele Cavalera et al.   Translational Research

Novel roles of hypoxia response system in glucose metabolism and obesity

(2014) Toshihiro Ichiki et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease: Basic Mechanisms and Clinical Associations

(2014) Timothy P. Fitzgibbons et al.   Journal of the American Heart Association

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Increased echocardiographic epicardial fat thickness and high-sensitivity CRP level indicate diastolic dysfunction in patients with newly diagnosed essential hypertension

(2013) Osman Turak et al.   BLOOD PRESSURE MONITORING

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

(2013) Nicolas Venteclef et al.   EUROPEAN HEART JOURNAL

Effect of Basic Fibroblast Growth Factor on the Myocardial Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Following Acute Myocardial Infarction

(2013) Heng-Chen Yao et al.   Heart Lung and Circulation

Inflammatory biomarkers CRP, MCP-1, serum amyloid alpha and interleukin-18 in patients with HTN and dyslipidemia: impact of diabetes mellitus on metabolic syndrome and the effect of statin therapy

(2013) Simon W Rabkin et al.   HYPERTENSION RESEARCH

Effect of epicardial adipose tissue on diastolic functions and left atrial dimension in untreated hypertensive patients with normal systolic function

(2013) Mustafa Çetin et al.   Journal of Cardiology

The Relationship Between Epicardial Fat and Indices of Obesity and the Metabolic Syndrome: A Systematic Review and Meta-Analysis

(2013) Simon W. Rabkin   Metabolic Syndrome and Related Disorders

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Insulin Regulates Hypoxia-Inducible Factor-1α Transcription by Reactive Oxygen Species Sensitive Activation of Sp1 in 3T3-L1 Preadipocyte

(2013) Sudipta Biswas et al.   PLoS One

Effects of Direct Renin Inhibition on Myocardial Fibrosis and Cardiac Fibroblast Function

(2013) Hui Zhi et al.   PLoS One

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

(2013) Z. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

(2012) Gerhard Krönke et al.   ANNALS OF THE RHEUMATIC DISEASES

Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis

(2012) Zi-Lun Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain

(2012) Girriso F. Benderro et al.   BRAIN RESEARCH

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

(2012) Hemant Poudyal et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

(2012) Xinli Qu et al.   JOURNAL OF PATHOLOGY

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

(2012) Mi-Kyung Shin et al.   PLoS One

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Novel links between HIFs, type 2 diabetes, and metabolic syndrome

(2012) Christian M. Girgis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia

(2011) Qing He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Omega-3 Fatty Acids Prevent Pressure Overload–Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts

(2011) Jinghai Chen et al.   CIRCULATION

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?

(2011) Patrick Collier et al.   EUROPEAN JOURNAL OF HEART FAILURE

Enhanced Inflammation in Epicardial Fat in Patients With Coronary Artery Disease

(2011) Yoichiro Hirata et al.   International Heart Journal

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

(2011) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Depot-Specific Overexpression of Proinflammatory, Redox, Endothelial Cell, and Angiogenic Genes in Epicardial Fat Adjacent to Severe Stable Coronary Atherosclerosis

(2011) Harold S. Sacks et al.   Metabolic Syndrome and Related Disorders

Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress

(2010) Lele Ji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin Use and Mortality Among Patients With Diabetes and AtherothrombosisMetformin Use With Diabetes and Atherothrombosis

(2010) Ronan Roussel   ARCHIVES OF INTERNAL MEDICINE

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

(2010) B. A. Borlaug et al.   EUROPEAN HEART JOURNAL

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat

(2010) Weike Bao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Hypoxia-induced Phenotypic Switch of Fibroblasts to Myofibroblasts through a Matrix Metalloproteinase 2/Tissue Inhibitor of Metalloproteinase–mediated Pathway: Implications for Venous Neointimal Hyperplasia in Hemodialysis Access

(2010) Sanjay Misra et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Physiological Adaptation of the Cardiovascular System to High Altitude

(2010) Robert Naeije   PROGRESS IN CARDIOVASCULAR DISEASES

Echocardiographic and Tissue Doppler Imaging of Cardiac Adaptation to High Altitude in Native Highlanders Versus Acclimatized Lowlanders

(2009) Sandrine Huez et al.   AMERICAN JOURNAL OF CARDIOLOGY

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Thrombospondins in the heart: potential functions in cardiac remodeling

(2009) Mark W. M. Schellings et al.   Journal of Cell Communication and Signaling

Connective tissue growth factor and cardiac fibrosis

(2008) A. Daniels et al.   Acta Physiologica

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element

(2008) Stefan Kaluz et al.   CLINICA CHIMICA ACTA

Hypoxia-Inducible Factor-Dependent Degeneration, Failure, and Malignant Transformation of the Heart in the Absence of the von Hippel-Lindau Protein

(2008) L. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia and the endocrine and signalling role of white adipose tissue

(2008) Paul Trayhurn et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY