Article
Medicine, General & Internal
Jessica Latorre, Jordi Mayneris-Perxachs, Nuria Oliveras-Canellas, Francisco Ortega, Ferran Comas, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: This study investigated the role of CDO1 gene expression in adipose tissue and found that higher CDO1 expression was associated with improved metabolic profiles, decreased fasting triglycerides and blood HbA1c levels, as well as gene expression markers of adipocyte function and inflammation in both visceral and subcutaneous adipose tissue.
Article
Multidisciplinary Sciences
Gemma Carreras-Badosa, Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Silvia Xargay-Torrent, Anna Prats-Puig, Elsa Puerto-Carranza, Francis de Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: GDF-15 is positively associated with immunoglobulin levels in apparently healthy children, especially in those with higher body mass index or renal fat accumulation, suggesting a potential role of GDF-15 in regulating the immune adaptive system in human obesity.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Rosaria Vari, Beatrice Scazzocchio, Annalisa Silenzi, Claudio Giovannini, Roberta Masella
Summary: Obesity is a main risk factor for chronic diseases, while curcumin shows potential anti-inflammatory properties that can combat inflammation caused by obesity.
Review
Endocrinology & Metabolism
RuiYan Mei, WeiWei Qin, YanHua Zheng, Zhuo Wan, Li Liu
Summary: Exosomes secreted by adipose tissue play a crucial role in metabolic disorders, regulating specific mechanisms related to obesity, adipose inflammation, and diabetes. Adipose tissue is a major source of circulating exosomal miRNAs, which not only alter the state of patients with metabolic diseases but also affect the communication between metabolic organs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Review
Endocrinology & Metabolism
Yuan-Yuan Wang, Ya-Di Wang, Xiao-Yan Qi, Zhe-Zhen Liao, Yun-Ni Mai, Xin-Hua Xiao
Summary: Obesity is linked to chronic inflammation and metabolic dysfunction, with alterations in adipose tissue macrophages playing a crucial role. Metabolic organs communicate with adipose tissue macrophages through secretion of organokines or exosomes, influencing obesity treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Ashraf Al Madhoun, Shihab Kochumon, Dania Haddad, Reeby Thomas, Rasheeba Nizam, Lavina Miranda, Sardar Sindhu, Milad S. Bitar, Rasheed Ahmad, Fahd Al-Mulla
Summary: Obesity is associated with chronic low-grade inflammation. Obese individuals have higher levels of CAV1 protein in adipose tissues. This study found a positive correlation between CAV1 gene expression and TNF-a. and NF -KB gene expression in obese adipose tissues.
Review
Environmental Sciences
Aayush Sehgal, Tapan Behl, Ishnoor Kaur, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Inflammasome activity is crucial in non-microbial diseases related to prolonged inflammation, especially in obesity and its associated metabolic disorders. Understanding the regulation of inflammasomes may lead to improved therapeutic strategies. Research is ongoing on compounds that can mitigate inflammasome expression, particularly to manage common disorders like obesity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Valmore Bermudez, Pablo Duran, Edward Rojas, Maria P. Diaz, Jose Rivas, Manuel Nava, Maricarmen Chacin, Mayela Cabrera de Bravo, Ruben Carrasquero, Climaco Cano Ponce, Jose Luis Gorriz, Luis D'Marco
Summary: This article discusses the pathophysiology and consequences of adipose tissue expansion, particularly its association with meta-inflammation and microbiota dysbiosis. It also explores the mechanisms involved in metabolic reprogramming in AT, which may be causative factors for cardiovascular disease. Finally, it clarifies how lifestyle changes can improve myocardial cell function and develop effective non-pharmacologic approaches to combating CVD through changes in AT proteomics and gut microbiome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Masaki Kobayashi, Yusuke Deguchi, Yuka Nozaki, Yoshikazu Higami
Summary: PGC-1 alpha plays a crucial role in regulating mitochondrial function and adipocyte-specific functions in white adipose tissue, with its function being affected by metabolic changes such as obesity and caloric restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Keke Wu, Biao Li, Yingxu Ma, Tao Tu, Qiuzhen Lin, Jiayi Zhu, Yong Zhou, Na Liu, Qiming Liu
Summary: This study aimed to investigate the role of NMN in regulating HIF-1 alpha and fibrosis in hypoxic adipose tissue. It was found that NMN attenuated hypoxia-induced adipose fibrosis and inflammation by restoring the compromised NAD(+)/SIRT1 axis and inhibiting HIF-1 alpha activation. These findings suggest that NMN may be a potential therapeutic agent for the treatment of adipose fibrosis and inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Jose Antonio Fagundes Assumpcao, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martin Hernan Bonamino, Kelly Grace Magalhaes
Summary: Obesity is a complex disease associated with metabolic and cardiovascular conditions as well as cancer development. Recent evidence shows that mild obesity is paradoxically associated with better treatment outcomes in cancer patients, termed as the obesity paradox. Obesity also impacts the response to cancer treatments and has a positive association with immune checkpoint therapy.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Byung Chul Jung, Sona Kang
Summary: Obesity is strongly associated with insulin resistance, and chronic low-grade tissue inflammation and systemic inflammation are proposed as major mechanisms. Adipose tissue serves as a crucial link between inflammation and metabolism, while epigenetic modifications play a key role in gene regulation in response to environmental changes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Endocrinology & Metabolism
Sierra A. Nance, Lindsey Muir, Carey Lumeng
Summary: This review provides an updated overview of ATM activation and function, ATM diversity in humans and rodents, and novel ATM functions that contribute to metabolic homeostasis and disease.
MOLECULAR METABOLISM
(2022)
Letter
Surgery
Sami Akbulut, Tevfik Tolga Sahin
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Letter
Surgery
Sami Akbulut, Tevfik Tolga Sahin
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Letter
Surgery
Sami Akbulut, Tevfik Tolga Sahin
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Pediatrics
Kutay Saglam, Tevfik Tolga Sahin, Sertac Usta, Cemalettin Koc, Emrah Otan, Cuneyt Kayaalp, Cemalettin Aydin, Sezai Yilmaz
Summary: Portal vein anastomotic complications related to size discrepancy are important causes of morbidity and mortality in pediatric liver transplantation. The use of interposed vein grafts can overcome portal flow problems, with preoperative portal vein thrombosis and insufficient flow being important factors affecting the success of liver transplant in children.
PEDIATRIC TRANSPLANTATION
(2022)
Review
Surgery
Adem Tuncer, Sami Akbulut, Zeki Ogut, Tevfik Tolga Sahin
Summary: Rectal prolapse, defined as the protrusion of mucosa or full-thickness rectal wall through the anal canal, negatively impacts quality of life and should be treated surgically once diagnosed. The surgical approach depends on patient compliance and surgical team experience. Chronic constipation may lead to disproportionately large rectal prolapse.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Review
Medicine, General & Internal
Sami Akbulut, Tevfik Tolga Sahin
Summary: The study aimed to evaluate the role of anesthesiologists in the management of hydatid disease, highlighting the controversy surrounding scientific research ethics in different departments. Collaboration among disciplines is crucial, and violating another field's subject without collaboration is a deontological problem.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Oncology
Emrah Sahin, Volkan Ince, Tolga T. Sahin, Ramazan Kutlu, Ramazan Pasahan, Sezai Yilmaz
Summary: The unexplained elevation of AFP after transplantation may indicate the possibility of brain metastasis. Performing cranial scanning with conventional imaging methods is more beneficial than using FDG PET.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Immunology
Sami Akbulut, Gulseda Boz, Ali Ozer, Tevfik Tolga Sahin, Cemil Colak
Summary: This study aimed to evaluate the attitude of the Turkish population towards COVID-19 vaccines and the reasons for vaccine hesitancy. Results showed that 58.4% of participants had hesitations towards COVID-19 vaccination and 19.6% had hesitations towards all childhood vaccinations. Those who did not receive the COVID-19 vaccine or had hesitations towards it had higher scores on the VHS-P and AVS-LF scales. Similarly, those who did not vaccinate their children or had hesitations towards childhood vaccinations also had higher scores on the VHS-P and AVS-LF scales.
Article
Medicine, General & Internal
Sami Akbulut, Zeynep Kucukakcali, Hasan Saritas, Cigdem Bozkir, Murat Tamer, Musap Akyuz, Nazlican Bagci, Selver Unsal, Mehmet Serdar Akbulut, Tevfik Tolga Sahin, Cemil Colak, Sezai Yilmaz
Summary: The aim of this study was to compare liver transplant recipients with and without hepatocellular carcinoma (HCC) in terms of COVID-19-related depression, anxiety, and stress. The results showed that patients without HCC, females, those with chronic diseases, those exposed to COVID-19, and those not vaccinated against COVID-19 were more likely to experience anxiety, depression, and stress. These results are reliable.
Meeting Abstract
Surgery
H. O. Keles, C. Cengiz, I. Demiral, M. M. Ozmen, A. Omurtag
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Canan Akman, Bulent Erbil, Mehmet Akif Topcuoglu, Mehmet Ali Karaca, Erhan Akpinar, Mehmet Mahir Ozmen
Summary: Differentiating primary and secondary causes of headaches in emergency situations is crucial, as secondary headaches may have serious underlying neurological causes. This study aimed to identify red flags in neuroimaging for life-threatening secondary causes in patients with headache complaints. It found that factors like severe headache, sudden onset, neurological deficits, and age over 50 are warning criteria that require thorough imaging evaluation, including both CT and MRI scans.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2021)
Article
Surgery
Mehmet Mahir Ozmen, Baris Zulfikaroglu, Fusun Ozmen, Munevver Moran, Necdet Ozalp, Selda Seckin
Summary: This study showed that D2 plus PALN dissection for advanced gastric cancer can be performed as safely as a standard D2 dissection by experienced surgeons without increasing postoperative morbidity and mortality. Additionally, D2 plus PALN dissection can increase the rate of survival in patients with stage IIIA and IIIB disease.
TURKISH JOURNAL OF SURGERY
(2021)
Review
Surgery
Mahir Ozmen, Emre Gundogdu, Emir Guldogan
Summary: Significant advancements have been made in bariatric surgery over the past two decades, with the increasing use of robotic surgery offering new opportunities for improved precision and outcomes. Robotic bariatric surgery allows for more efficient procedures and ideal anastomosis in challenging fields, with safety and outcomes comparable to laparoscopy.
Letter
Surgery
Sami Akbulut, Tevfik Tolga Sahin
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)