Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population

Variants at HLA-A , HLA-C , and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese

(2018) Jun Hirata et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

(2018) Yukinori Okada et al.   Nature Communications

Revealing complete complex KIR haplotypes phased by long-read sequencing technology

(2017) D Roe et al.   GENES AND IMMUNITY

HLA-HD: An accurate HLA typing algorithm for next-generation sequencing data

(2017) Shuji Kawaguchi et al.   HUMAN MUTATION

Clinical response to PD-1 blockade correlates with a sub-fraction of peripheral central memory CD4+ T cells in patients with malignant melanoma

(2017) Yoshiko Takeuchi et al.   INTERNATIONAL IMMUNOLOGY

Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases

(2017) Makoto Hirata et al.   JOURNAL OF EPIDEMIOLOGY

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Reevaluation of SNP heritability in complex human traits

(2017) Doug Speed et al.   NATURE GENETICS

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

(2017) Jason H. Karnes et al.   Science Translational Medicine

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles

(2017) James Robinson et al.   PLoS Genetics

Comparison of HLA allelic imputation programs

(2017) Jason H. Karnes et al.   PLoS One

Contribution of a Non-classical HLA Gene, HLA-DOA , to the Risk of Rheumatoid Arthritis

(2016) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

(2016) A Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set

(2016) Masahiro Kanai et al.   JOURNAL OF HUMAN GENETICS

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

(2016) Fusheng Zhou et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Unravelling the human genome–phenome relationship using phenome-wide association studies

(2016) William S. Bush et al.   NATURE REVIEWS GENETICS

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis

(2016) Nao Nishida et al.   Scientific Reports

The impact of next-generation sequencing technologies on HLA research

(2015) Kazuyoshi Hosomichi et al.   JOURNAL OF HUMAN GENETICS

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

(2015) Sachet A Shukla et al.   NATURE BIOTECHNOLOGY

Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese

(2015) Yukinori Okada et al.   NATURE GENETICS

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

(2015) Xinli Hu et al.   NATURE GENETICS

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

(2015) Tobias L Lenz et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

(2014) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

OptiType: precision HLA typing from next-generation sequencing data

(2014) András Szolek et al.   BIOINFORMATICS

A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B

(2014) Kazuyoshi Hosomichi et al.   BMC GENOMICS

MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques

(2014) Shunji Ikeshita et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

Phase-defined complete sequencing of the HLA genes by next-generation sequencing

(2013) Kazuyoshi Hosomichi et al.   BMC GENOMICS

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Visualization of SNPs with t-SNE

(2013) Alexander Platzer   PLoS One

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HLA-Cw*1202-B*5201-DRB1*1502 Haplotype Increases Risk for Ulcerative Colitis but Reduces Risk for Crohn's Disease

(2011) Yukinori Okada et al.   GASTROENTEROLOGY

Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population

(2011) Yukinori Okada et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New allele name of some HLA-DRB1*1401: HLA-DRB1*1454

(2009) K. L. Yang et al.   International Journal of Immunogenetics