Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

(2015) Philippe Goyette et al.   NATURE GENETICS

Genome-wide significant risk associations for mucinous ovarian carcinoma

(2015) Linda E Kelemen et al.   NATURE GENETICS

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

(2015) Javier Gutierrez-Achury et al.   NATURE GENETICS

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

(2014) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA

(2014) Hiroko Miyadera et al.   JOURNAL OF CLINICAL INVESTIGATION

Another explanation for apparent epistasis

(2014) Andrew R. Wood et al.   NATURE

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

(2014) Ines Gockel et al.   NATURE GENETICS

The contribution of genetic variants to disease depends on the ruler

(2014) John S. Witte et al.   NATURE REVIEWS GENETICS

Major Histocompatibility Complex Genomics and Human Disease

(2013) John Trowsdale et al.   Annual Review of Genomics and Human Genetics

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Genetics and epigenetics of rheumatoid arthritis

(2013) Sebastien Viatte et al.   Nature Reviews Rheumatology

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element

(2013) Alex Clop et al.   PLoS One

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity

(2013) Sue Tsai et al.   Frontiers in Immunology

Interrogating the major histocompatibility complex with high-throughput genomics

(2012) P. I. W. de Bakker et al.   HUMAN MOLECULAR GENETICS

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

COMPUTATIONAL PREDICTION OF MHC II-ANTIGEN BINDING SUPPORTS DIVERGENT ALLELE ADVANTAGE AND EXPLAINS TRANS-SPECIES POLYMORPHISM

(2011) Tobias L. Lenz   EVOLUTION

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

(2011) Hon-Cheong So et al.   GENETIC EPIDEMIOLOGY

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

MHC genotypes associate with resistance to a frog-killing fungus

(2011) A. E. Savage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rheumatoid arthritis HLA–DRB1 shared epitope

(2010) Joseph Holoshitz   CURRENT OPINION IN RHEUMATOLOGY

Allele Interaction – Single Locus Genetics Meets Regulatory Biology

(2010) Arne B. Gjuvsland et al.   PLoS One

Multi-locus models of genetic risk of disease

(2010) Naomi R Wray et al.   Genome Medicine

Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes

(2009) P. G. Bronson et al.   DIABETES OBESITY & METABOLISM

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

(2008) P. I.W. de Bakker et al.   HUMAN MOLECULAR GENETICS

Does intra-individual major histocompatibility complex diversity keep a golden mean?

(2008) B. Woelfing et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms

(2008) Alienke J. Monsuur et al.   PLoS One