Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases

(2017) Clara Abraham et al.   GASTROENTEROLOGY

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

(2017) Valérie Turcot et al.   NATURE GENETICS

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

(2017) Wei Zhao et al.   NATURE GENETICS

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

(2017) Anne E. Justice et al.   Nature Communications

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

(2017) Mariaelisa Graff et al.   PLoS Genetics

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

(2017) Maggie C. Y. Ng et al.   PLoS Genetics

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCLINICAL PERSPECTIVE

(2017) Aldi T. Kraja et al.   Circulation-Cardiovascular Genetics

A Robust Example of Collider Bias in a Genetic Association Study

(2016) Felix R. Day et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility

(2016) James P Cook et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Protective role of R381Q (rs11209026) polymorphism inIL-23Rgene in immune-mediated diseases: A comprehensive review

(2016) Elham Abdollahi et al.   Journal of Immunotoxicology

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation

(2016) Melvin Anyasi Ambele et al.   Stem Cell Research

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

(2016) Yingchang Lu et al.   Nature Communications

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

(2016) Wanqing Wen et al.   Scientific Reports

Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies

(2015) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   BIOPRESERVATION AND BIOBANKING

Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis

(2015) W.-J. Yang et al.   EMBO Molecular Medicine

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

(2015) K. T. Nead et al.   HUMAN MOLECULAR GENETICS

Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1

(2015) Xun Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism

(2015) Floriane Baraille et al.   PHYSIOLOGY

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

(2015) Celestina Mazzotta et al.   ARTHRITIS RESEARCH & THERAPY

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism

(2015) Kevin Y. Lee et al.   Nature Communications

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   Biopreservation and Biobanking

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

(2015) Anubha Mahajan et al.   PLoS Genetics

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

(2015) Thomas W. Winkler et al.   PLoS Genetics

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

(2015) Chuan Gao et al.   PLoS One

RAREMETAL: fast and powerful meta-analysis for rare variants

(2014) S. Feng et al.   BIOINFORMATICS

EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data

(2014) Thomas W. Winkler et al.   BIOINFORMATICS

The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease

(2014) J. A. Bonomo et al.   HUMAN MOLECULAR GENETICS

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

(2014) Fredrik Karpe et al.   Nature Reviews Endocrinology

CDD: NCBI's conserved domain database

(2014) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

(2014) M. Catoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of the FGFR2 gene is associated with high birth weight centile in humans

(2014) Kim E Haworth et al.   Epigenomics

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

(2014) Maggie C. Y. Ng et al.   PLoS Genetics

Relationship between the percentage of body fat and surrogate indices of fatness in male and female Polish active and sedentary students

(2014) Grażyna Lutoslawska et al.   Journal of Physiological Anthropology

Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene

(2013) Asaf Ta-Shma et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Semaphorin 3E Suppresses Tumor Cell Death Triggered by the Plexin D1 Dependence Receptor in Metastatic Breast Cancers

(2013) Jonathan Luchino et al.   CANCER CELL

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

(2013) R. Saxena et al.   DIABETES

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

Meta-analysis of gene-level tests for rare variant association

(2013) Dajiang J Liu et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes

(2013) Satomi Yogosawa et al.   Adipocyte

Expression of Activin Receptor-like Kinase 7 in Adipose Tissues

(2012) Masaru Murakami et al.   BIOCHEMICAL GENETICS

zCall: a rare variant caller for array-based genotyping

(2012) Jacqueline I. Goldstein et al.   BIOINFORMATICS

Decreased Transcription of ChREBP- /  Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

(2012) R. Kursawe et al.   DIABETES

Activin Receptor-Like Kinase 7 Suppresses Lipolysis to Accumulate Fat in Obesity Through Downregulation of Peroxisome Proliferator–Activated Receptor γ and C/EBPα

(2012) Satomi Yogosawa et al.   DIABETES

Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans

(2012) D. van Raalte et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Cohort Profile: TwinsUK and Healthy Ageing Twin Study

(2012) A. Moayyeri et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

(2012) Andy Boyd et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1

(2011) Tomasz Zygmunt et al.   DEVELOPMENTAL CELL

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism

(2011) J. Kim et al.   GENES & DEVELOPMENT

Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability

(2011) Zoltán Kutalik et al.   GENETIC EPIDEMIOLOGY

Full spectrum genetics

(2011)   NATURE GENETICS

Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration

(2011) S. Gesta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of puberty on body composition

(2011) Lindsey A Loomba-Albrecht et al.   Current Opinion in Endocrinology Diabetes and Obesity

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

Gluteofemoral body fat as a determinant of metabolic health

(2010) K N Manolopoulos et al.   INTERNATIONAL JOURNAL OF OBESITY

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

(2009) Lena M.S. Carlsson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G771C Polymorphism in the MLXIPL Gene Is Associated with a Risk of Coronary Artery Disease in the Chinese: A Case-Control Study

(2009) Ling-Ai Pan et al.   CARDIOLOGY

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series

(2009) T. Karaderi et al.   RHEUMATOLOGY

Distribution of body fat and risk of coronary heart disease in men and women

(2008) Dexter Canoy   CURRENT OPINION IN CARDIOLOGY

Role of the cAMP sensor Epac as a determinant of KATPchannel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells

(2008) Guoxin Kang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes

(2008) R. K. Petersen et al.   MOLECULAR AND CELLULAR BIOLOGY

PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation

(2008) Claudia N. Martini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

(2008) Jaspal S Kooner et al.   NATURE GENETICS

General and Abdominal Adiposity and Risk of Death in Europe

(2008) T. Pischon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence of Central and Extremity Circumferences on All-cause Mortality in Men and Women

(2008) Caitlin Mason et al.   Obesity

Activin B receptor ALK7 is a negative regulator of pancreatic  -cell function

(2008) P. Bertolino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA