The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis

Cholesterol metabolism in pathogenesis of osteoarthritis disease

(2017) Saba Farnaghi et al.   International Journal of Rheumatic Diseases

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

(2017) Young-Ok Son et al.   Nature Communications

Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study

(2017) Jingbo Niu et al.   Arthritis & Rheumatology

Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis

(2017) Patricia Das Neves Borges et al.   PLoS One

Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study

(2017) M. Garcia-Gil et al.   Scientific Reports

Lectin-like Oxidized Low-Density Lipoprotein (LDL) Receptor (LOX-1): A Chameleon Receptor for Oxidized LDL

(2016) Bushra Zeya et al.   BIOCHEMISTRY

Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids

(2016) Owein Guillemot-Legris et al.   TRENDS IN MOLECULAR MEDICINE

The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages

(2016) Aleksandra Rutkowska et al.   Scientific Reports

RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages

(2016) Zewen Kelvin Tuong et al.   PLoS One

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis?

(2015) Wouter de Munter et al.   RHEUMATOLOGY

Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice

(2015) Paxton M. Moon et al.   Current Rheumatology Reports

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage

(2015) Shabana Amanda Ali et al.   Arthritis & Rheumatology

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

Hypoxia-Inducible Factor-2α Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis

(2014) Je-Hwang Ryu et al.   PLOS BIOLOGY

A commentary on modelling osteoarthritis pain in small animals

(2013) A.M. Malfait et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of cholesterol homeostasis

(2011) Leigh Goedeke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols