Hypoxia-Inducible Factor-2α Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification

(2012) Hwanhee Oh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

CD147 induces angiogenesis through a vascular endothelial growth factor and hypoxia-inducible transcription factor 1α-mediated pathway in rheumatoid arthritis

(2011) Cong-hua Wang et al.   ARTHRITIS AND RHEUMATISM

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor

(2010) Johanna Westra et al.   BMC MUSCULOSKELETAL DISORDERS

Osteoclastogenesis and arthritis

(2010) Nicola Maruotti et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Angiogenesis and vasculogenesis in rheumatoid arthritis

(2010) Zoltán Szekanecz et al.   CURRENT OPINION IN RHEUMATOLOGY

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Developments in the scientific understanding of rheumatoid arthritis

(2009) Jörg J Goronzy et al.   ARTHRITIS RESEARCH & THERAPY

The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis

(2009) Barbara Muz et al.   ARTHRITIS RESEARCH & THERAPY

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL