Metabo-lipidomics of Fibroblasts and Mitochondrial-Endoplasmic Reticulum Extracts from ALS Patients Shows Alterations in Purine, Pyrimidine, Energetic, and Phospholipid Metabolisms

Energy metabolism in ALS: an underappreciated opportunity?

(2018) Tijs Vandoorne et al.   ACTA NEUROPATHOLOGICA

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways

(2018) Hailong Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1 G93A mutant mice

(2018) Rachit Bakshi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Aerobic glycolysis in amyotrophic lateral sclerosis and Huntington’s disease

(2018) Alexandre Vallée et al.   REVIEWS IN THE NEUROSCIENCES

Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations

(2018) Andrea Stoccoro et al.   Epigenomics

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency

(2018) Cinzia Bocca et al.   Scientific Reports

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics

(2018) Jarosław Walczak et al.   FASEB JOURNAL

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

(2017) Blandine Madji Hounoum et al.   GLIA

Deep sequencing shows that oocytes are not prone to accumulate mtDNA heteroplasmic mutations during ovarian ageing

(2017) L. Boucret et al.   HUMAN REPRODUCTION

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

(2017) Jędrzej Szymański et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolomics and Lipidomics Profiling of a Combined Mitochondrial Plus Endoplasmic Reticulum Fraction of Human Fibroblasts: A Robust Tool for Clinical Studies

(2017) Charlotte Veyrat-Durebex et al.   JOURNAL OF PROTEOME RESEARCH

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients

(2017) Csaba Konrad et al.   Molecular Neurodegeneration

Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP

(2017) Sanjay Sonney et al.   PLoS Computational Biology

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

(2017) H. Blasco et al.   Scientific Reports

Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers

(2016) Fabiola Puentes et al.   BRAIN PATHOLOGY

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles

(2016) Rona Aviram et al.   MOLECULAR CELL

Serum Compounds of Energy Metabolism Impairment Are Related to Disability, Disease Course and Neuroimaging in Multiple Sclerosis

(2016) Giacomo Lazzarino et al.   MOLECULAR NEUROBIOLOGY

Purinergic contribution to amyotrophic lateral sclerosis

(2016) Cinzia Volonté et al.   NEUROPHARMACOLOGY

HmtDB 2016: data update, a better performing query system and human mitochondrial DNA haplogroup predictor

(2016) Rosanna Clima et al.   NUCLEIC ACIDS RESEARCH

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples

(2016) Lisa Kappler et al.   Scientific Reports

Plasmalogen phospholipids protect internodal myelin from oxidative damage

(2015) Adrienne M. Luoma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

(2015) Alexandre Henriques et al.   HUMAN MOLECULAR GENETICS

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients

(2015) Scott P. Allen et al.   NEUROBIOLOGY OF AGING

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

(2015) James C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad

(2015) Anjoscha Kaus et al.   Frontiers in Cellular Neuroscience

Bioenergetic markers in skin fibroblasts of sporadic amyotrophic lateral sclerosis and progressive lateral sclerosis patients

(2014) Kathryne Kirk et al.   ANNALS OF NEUROLOGY

Phy-Mer: a novel alignment-free and reference-independent mitochondrial haplogroup classifier

(2014) Daniel Navarro-Gomez et al.   BIOINFORMATICS

MitImpact: an Exhaustive Collection of Pre-computed Pathogenicity Predictions of Human Mitochondrial Non-synonymous Variants

(2014) Stefano Castellana et al.   HUMAN MUTATION

Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury

(2014) H. Arima et al.   NEUROSCIENCE

The mitochondrial epigenome: a role in Alzheimer's disease?

(2014) Matthew Devall et al.   Epigenomics

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

(2013) Scott P. Allen et al.   NEUROBIOLOGY OF AGING

Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis

(2012) S. Körner et al.   EUROPEAN JOURNAL OF NEUROLOGY

Lipidomics of intact mitochondria by MALDI-TOF/MS

(2012) Roberto Angelini et al.   JOURNAL OF LIPID RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

High levels of mitochondrial heteroplasmy modify the development of ovine - bovine interspecies nuclear transferred embryos

(2011) Song Hua et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxisomes and reactive oxygen species, a lasting challenge

(2009) Sabine Angermüller et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Uric Acid: The Oxidant-Antioxidant Paradox

(2008) Yuri Y. Sautin et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS