The role of TGFβ in hematopoiesis and myeloid disorders

Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients

(2018) Jiayi Yu et al.   Journal of Hematology & Oncology

Sotatercept with long-term extension for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes: a phase 2, dose-ranging trial

(2018) Rami Komrokji et al.   Lancet Haematology

Investigational drugs in phase I and phase II clinical trials for thalassemia

(2017) Irene Motta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration

(2017) Svitlana Pasteuning-Vuhman et al.   FASEB JOURNAL

Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study

(2017) Uwe Platzbecker et al.   LANCET ONCOLOGY

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

(2017) Y Mei et al.   LEUKEMIA

Increasing the effectiveness of hematopoiesis in myelodysplastic syndromes: erythropoiesis-stimulating agents and transforming growth factor-β superfamily inhibitors

(2017) Anna Mies et al.   SEMINARS IN HEMATOLOGY

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP

(2017) Deepankar Gahloth et al.   STRUCTURE

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

(2017) Shomyseh Sanjabi et al.   Cold Spring Harbor Perspectives in Biology

TGF-  inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors

(2016) X. Gao et al.   BLOOD

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

(2016) Esther A. Obeng et al.   CANCER CELL

Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells

(2016) Kazuhito Naka et al.   CANCER SCIENCE

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Activin Receptor II Ligand Traps and Their Therapeutic Potential in Myelodysplastic Syndromes with Ring Sideroblasts

(2016) Anna Mies et al.   Current Hematologic Malignancy Reports

Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression

(2015) George S. Karagiannis et al.   BIOLOGICAL CHEMISTRY

TGF-  signaling in the control of hematopoietic stem cells

(2015) U. Blank et al.   BLOOD

The TGF-β superfamily in dendritic cell biology

(2015) Pascal Seeger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies

(2015) Haralambos Raftopoulos et al.   SUPPORTIVE CARE IN CANCER

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

(2015) Michael Lahn et al.   Drug Design Development and Therapy

RAP-011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice

(2014) Jacqueline M. Langdon et al.   AMERICAN JOURNAL OF HEMATOLOGY

A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers

(2014) Kenneth M. Attie et al.   AMERICAN JOURNAL OF HEMATOLOGY

Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E

(2014) J. Li et al.   BLOOD

An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin

(2014) Soraya Carrancio et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sotatercept in patients with osteolytic lesions of multiple myeloma

(2014) Kudrat M. Abdulkadyrov et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

(2014) Janet L. Crane et al.   JOURNAL OF CLINICAL INVESTIGATION

Myelodysplasia is in the niche: novel concepts and emerging therapies

(2014) E Bulycheva et al.   LEUKEMIA

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

(2014) H Dolatshad et al.   LEUKEMIA

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

(2014) Rajasekhar N V S Suragani et al.   NATURE MEDICINE

Targeting a new regulator of erythropoiesis to alleviate anemia

(2014) Robert F Paulson   NATURE MEDICINE

miR-21 mediates hematopoietic suppression in MDS by activating TGF-  signaling

(2013) T. D. Bhagat et al.   BLOOD

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

(2013) Jeong-Hwan Yoon et al.   EMBO Molecular Medicine

Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap

(2012) Camelia Iancu-Rubin et al.   EXPERIMENTAL HEMATOLOGY

Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis

(2012) Peter C. Gray et al.   FEBS LETTERS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mechanisms of Smad binding

(2012) M Morikawa et al.   ONCOGENE

Regulation of TGF-β receptor activity

(2012) Fei Huang et al.   Cell and Bioscience

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Common structural traits for cystine knot domain of the TGFβ superfamily of proteins and three-fingered ectodomain of their cellular receptors

(2011) A. Galat   CELLULAR AND MOLECULAR LIFE SCIENCES

Dendritic cell lineage commitment is instructed by distinct cytokine signals

(2011) Kristin M. Seré et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Normal and malignant megakaryopoiesis

(2011) Qiang Wen et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

TGF- 1-induced PI3K/Akt/NF- B/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts

(2011) X. Zhu et al.   JOURNAL OF BIOCHEMISTRY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

(2010) Sutada Lotinun et al.   BONE

Reduced SMAD7 Leads to Overactivation of TGF-  Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-  Receptor I Kinase

(2010) L. Zhou et al.   CANCER RESEARCH

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter

(2010) Adèle Hannigan et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF- 1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors and Directs Subset Specification toward Conventional Dendritic Cells

(2010) P. Felker et al.   JOURNAL OF IMMUNOLOGY

Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2

(2010) Sumedha G. Penheiter et al.   MOLECULAR BIOLOGY OF THE CELL

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Regulation of TGF-  signaling by Smad7

(2009) X. Yan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Complex and Context Dependent Regulation of Hematopoiesis by TGF-β Superfamily Signaling

(2009) Sofie Singbrant Söderberg et al.   Annals of the New York Academy of Sciences

TGF-β receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-β

(2009) Andres Rojas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of the TGF-  receptor I kinase promotes hematopoiesis in MDS

(2008) L. Zhou et al.   BLOOD

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study of ACE-011 (ActRIIA-IgG1) in Postmenopausal Women*

(2008) Jon Ruckle et al.   JOURNAL OF BONE AND MINERAL RESEARCH