Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

(2011) S. Wey et al.   BLOOD

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells

(2011) K. Hu et al.   BLOOD

Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78

(2011) Kenichi Miharada et al.   Cell Stem Cell

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

An evolving web of signaling networks regulated by Cripto-1

(2011) Tadahiro Nagaoka et al.   GROWTH FACTORS

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

(2011) Mitchell G. Lawrence et al.   PROSTATE

Activin/Nodal Signaling Controls Divergent Transcriptional Networks in Human Embryonic Stem Cells and in Endoderm Progenitors

(2011) Stephanie Brown et al.   STEM CELLS

Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions

(2011) Kian Leong Lee et al.   PLoS Genetics

Role of Cripto-1 in Stem Cell Maintenance and Malignant Progression

(2010) Caterina Bianco et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes

(2010) Jonas Fuxe et al.   CELL CYCLE

The critical role of GRP78 in physiologic and pathologic stress

(2010) Kyle T Pfaffenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis

(2010) Jianhua Chu et al.   DEVELOPMENTAL BIOLOGY

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

(2010) Dueng-Yuan Hueng et al.   JOURNAL OF NEURO-ONCOLOGY

Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling

(2010) Meng-Ju Wu et al.   Molecular Cancer

Nodal promotes growth and invasion in human gliomas

(2010) C-C Lee et al.   ONCOGENE

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

(2009) J. Kern et al.   BLOOD

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis

(2009) Ravshan Burikhanov et al.   CELL

Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1

(2009) Kazuhide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

(2009) J A Kelber et al.   ONCOGENE

Graded Smad2/3 Activation Is Converted Directly into Levels of Target Gene Expression in Embryonic Stem Cells

(2009) Marcela Guzman-Ayala et al.   PLoS One

A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells

(2009) Shelley R. Hough et al.   PLoS One

Expression of nodal signalling components in cycling human endometrium and in endometrial cancer

(2009) Irene Papageorgiou et al.   Reproductive Biology and Endocrinology

Activin A, Activin Receptor Type II, Nodal, and Cripto mRNA Are Expressed by Eutopic and Ectopic Endometrium in Women With Ovarian Endometriosis

(2009) Paulo B. Torres et al.   Reproductive Sciences

Riding Shotgun: A Dual Role for the Epidermal Growth Factor-Cripto/FRL-1/Cryptic Protein Cripto in Nodal Trafficking

(2009) Daniel B. Constam   TRAFFIC

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

Regulation of Cripto-1 Signaling and Biological Activity by Caveolin-1 in Mammary Epithelial Cells

(2008) Caterina Bianco et al.   AMERICAN JOURNAL OF PATHOLOGY

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Cripto-independent Nodal signaling promotes positioning of the A–P axis in the early mouse embryo

(2008) Giovanna L. Liguori et al.   DEVELOPMENTAL BIOLOGY

Identification of Proteins Associating with Glycosylphosphatidylinositol- Anchored T-Cadherin on the Surface of Vascular Endothelial Cells: Role for Grp78/BiP in T-Cadherin-Dependent Cell Survival

(2008) M. Philippova et al.   MOLECULAR AND CELLULAR BIOLOGY

Cripto-1 Alters Keratinocyte Differentiation via Blockade of Transforming Growth Factor- 1 Signaling: Role in Skin Carcinogenesis

(2008) A. Shukla et al.   MOLECULAR CANCER RESEARCH

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity

(2008) O. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

(2008) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells

(2008) L.-M. Postovit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE