Transmission of α-synuclein seeds in neurodegenerative disease: recent developments
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Title
Transmission of α-synuclein seeds in neurodegenerative disease: recent developments
Authors
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Journal
LABORATORY INVESTIGATION
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-02-14
DOI
10.1038/s41374-019-0195-z
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Note: Only part of the references are listed.- Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity
- (2018) Esteban Luna et al. ACTA NEUROPATHOLOGICA
- Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
- (2018) Georgia Minakaki et al. Autophagy
- Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength
- (2018) Alexander M. Barclay et al. Biomolecular NMR Assignments
- Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates
- (2018) Barbara E. Stopschinski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal
- (2018) Shi Zhang et al. NEUROBIOLOGY OF AGING
- Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
- (2018) Diego Grassi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy
- (2018) Natascha Fussi et al. Cell Death & Disease
- Cryo-EM structure of alpha-synuclein fibrils
- (2018) Ricardo Guerrero-Ferreira et al. eLife
- α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
- (2018) Jessica M. Froula et al. Acta Neuropathologica Communications
- DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins
- (2018) Yue Xu et al. Cell Discovery
- Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy
- (2018) Yaowang Li et al. CELL RESEARCH
- Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
- (2018) Binsen Li et al. Nature Communications
- Membrane binding, internalization, and sorting of alpha-synuclein in the cell
- (2018) Caterina Masaracchia et al. Acta Neuropathologica Communications
- Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
- (2017) Richard J. Karpowicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication
- (2017) Amanda L. Woerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation
- (2017) Sarah Jinn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates
- (2017) Peizhou Jiang et al. Scientific Reports
- Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
- (2017) Jennifer Ngolab et al. Acta Neuropathologica Communications
- α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication
- (2017) Suzana Aulić et al. Scientific Reports
- Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
- (2016) Michel Brahic et al. ACTA NEUROPATHOLOGICA
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology
- (2016) Amanda N. Sacino et al. JOURNAL OF NEUROCHEMISTRY
- Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells
- (2016) Jin-Gu Lee et al. NATURE CELL BIOLOGY
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
- (2016) Kelvin C. Luk et al. Cell Reports
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells
- (2016) Mihaela M. Apetri et al. PLoS One
- Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril
- (2016) Changyoun Kim et al. Scientific Reports
- TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function
- (2015) Chunlei Cang et al. CELL
- Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
- (2015) A-L Mahul-Mellier et al. CELL DEATH AND DIFFERENTIATION
- Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
- (2015) Filsy Samuel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
- (2015) Stanley B. Prusiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
- (2015) E-J Bae et al. Cell Death & Disease
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- ATP13A2/PARK9 Regulates Secretion of Exosomes and -Synuclein
- (2014) T. Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
- (2014) Emiko Miura et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein
- (2012) Eun-Jin Bae et al. ANTIOXIDANTS & REDOX SIGNALING
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, -Synuclein Accumulation, and Neurotoxicity
- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
- (2012) Masatoshi Konno et al. Molecular Neurodegeneration
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- A Unifying Role for Prions in Neurodegenerative Diseases
- (2012) S. B. Prusiner SCIENCE
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
- (2011) He-Jin Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
- (2010) Jia-Yi Li et al. MOVEMENT DISORDERS
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
- (2008) Jeffrey H. Kordower et al. MOVEMENT DISORDERS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
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