Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

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α-synuclein aggregation and its modulation

(2017) Dhiman Ghosh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells

(2017) Matthias Höllerhage et al.   Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models

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Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases

(2015) Maria Xilouri et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

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Regulation of exosome release by glycosphingolipids and flotillins

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Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity

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Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Applying chaperones to protein-misfolding disorders: Molecular chaperones against α-synuclein in Parkinson's disease

(2013) Ali Chaari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Alpha-Synuclein is Involved in Manganese-Induced ER Stress via PERK Signal Pathway in Organotypic Brain Slice Cultures

(2013) Bin Xu et al.   MOLECULAR NEUROBIOLOGY

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

(2013) Jianhua Li et al.   NATURE IMMUNOLOGY

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

The Function of α-Synuclein

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Genetics of Parkinson's Disease

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Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies

(2013) Darius Ebrahimi-Fakhari et al.   Acta Neuropathologica Communications

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Molecular mechanisms of selective autophagy

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Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics

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Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

(2012) Marina S Gorbatyuk et al.   MOLECULAR THERAPY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Molecular Chaperones and Co-Chaperones in Parkinson Disease

(2012) Hemi Dimant et al.   NEUROSCIENTIST

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

(2011) Soledad Matus et al.   CURRENT OPINION IN CELL BIOLOGY

Chaperone-mediated autophagy at a glance

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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

(2011) Karen M. Doyle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn)

(2011) S. Batelli et al.   NEUROSCIENCE

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Parkinson's disease: from monogenic forms to genetic susceptibility factors

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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