Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Cancer and aging in Ibero-America

(2018) E. Soto-Perez-de-Celis et al.   Clinical & Translational Oncology

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

The effects of treadmill exercise on autophagy in hippocampus of APP/PS1 transgenic mice

(2018) Na Zhao et al.   NEUROREPORT

Long-term treadmill exercise attenuates Aβ burdens and astrocyte activation in APP/PS1 mouse model of Alzheimer’s disease

(2018) Jing Zhang et al.   NEUROSCIENCE LETTERS

d -galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions

(2018) Yao Xu et al.   TOXICOLOGY LETTERS

Exercise for managing cancer- and treatment-related side effects in older adults

(2018) Kah Poh Loh et al.   Journal of Geriatric Oncology

Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics

(2018) Jun Ren et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment

(2017) Virginia Camacho et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Markers of T Cell Senescence in Humans

(2017) Weili Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

(2017) Jingjing Fan et al.   Oncotarget

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Aging, Obesity, and Inflammatory Age-Related Diseases

(2017) Daniela Frasca et al.   Frontiers in Immunology

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

(2016) Léia Cristina Rodrigues Silva et al.   AGE

Effects of aerobic training on markers of autophagy in the elderly

(2016) Yubisay Mejías-Peña et al.   AGE

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation

(2016) Heather W. Stout-Delgado et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p38δ MAPKHighlights

(2016) Kristiina Rajamäki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

(2016) Mohammed Akbar et al.   BRAIN RESEARCH

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice

(2016) Tong-Yan Liu et al.   DIABETES

Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection

(2016) Daniel A. East et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition

(2016) Jeong-sun Ju et al.   Journal of Physiological Sciences

Apoptosis of T-Cell Subsets after Acute High-Intensity Interval Exercise

(2016) KARSTEN KRÜGER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Late running is not too late against Alzheimer's pathology

(2016) Arne Herring et al.   NEUROBIOLOGY OF DISEASE

Oligonol promotes anti-aging pathwaysviamodulation of SIRT1-AMPK-Autophagy Pathway

(2016) Seul-Ki Park et al.   Nutrition Research and Practice

Autophagy and Immune Senescence

(2016) Hanlin Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy-associated immune responses and cancer immunotherapy

(2016) Hongming Pan et al.   Oncotarget

The Effects of Physical Activity in Parkinson’s Disease: A Review

(2016) Martine Lauzé et al.   Journal of Parkinsons Disease

Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration

(2016) Krzysztof Marycz et al.   Stem Cells International

Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization

(2016) Russell Emmons et al.   Stem Cells International

Cancer Prevention in the Older Individual

(2016) Lodovico Balducci   Seminars in Oncology Nursing

Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient

(2015) Jon Hazeldine et al.   AGEING RESEARCH REVIEWS

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation

(2015) Chi G Weindel et al.   Autophagy

Stem cells, mitochondria and aging

(2015) Kati J. Ahlqvist et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Long-term treadmill exercise improves spatial memory of male appswe/ps1de9 mice by regulation of bdnf expression and microglia activation

(2015) Jingyu Xiong et al.   BIOLOGY OF SPORT

Environmental immune disruptors, inflammation and cancer risk

(2015) Patricia A. Thompson et al.   CARCINOGENESIS

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation

(2015) Céline Schwalm et al.   FASEB JOURNAL

Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues

(2015) O. A. Gonzalez et al.   IMMUNOLOGICAL INVESTIGATIONS

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

The Biology of Aging and Lymphoma: a Complex Interplay

(2015) Clémentine Sarkozy et al.   Current Oncology Reports

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

(2015) Francesca Bonomini et al.   Aging and Disease

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

Exercise training as treatment in cancer cachexia

(2014) Fábio Santos Lira et al.   Applied Physiology Nutrition and Metabolism

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T Cells and the Immune Aging Process: A Mini-Review

(2014) Ann Jagger et al.   GERONTOLOGY

Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

(2014) Jesper Olesen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

(2013) Frankie F. Brown et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

The effects of cocoa supplementation, caloric restriction, and regular exercise, on oxidative stress markers of brain and memory in the rat model

(2013) Zsolt Radák et al.   FOOD AND CHEMICAL TOXICOLOGY

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson’s disease

(2013) C.C. Real et al.   NEUROSCIENCE

Effects of Interval and Continuous Exercise Training on CD4 Lymphocyte Apoptotic and Autophagic Responses to Hypoxic Stress in Sedentary Men

(2013) Tzu-Pin Weng et al.   PLoS One

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

(2013) R. Tarawneh et al.   Cold Spring Harbor Perspectives in Medicine

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging

(2012) Kanchan Phadwal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages

(2011) C. Cudejko et al.   BLOOD

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

(2011) Cécile Jamart et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

(2011) J. Eric Ahlskog et al.   MAYO CLINIC PROCEEDINGS

Role of phosphoinositide 3-kinase–Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors

(2011) Mosoka P. Fallah et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Combined Exercise and Insulin-Like Growth Factor-1 Supplementation Induces Neurogenesis in Old Rats, but Do Not Attenuate Age-Associated DNA Damage

(2011) Erika Koltai et al.   REJUVENATION RESEARCH

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood

(2010) Jong-Shyan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise

(2010) Maria R. Bonsignore et al.   JOURNAL OF APPLIED PHYSIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats

(2009) José C. Rosa Neto et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Key role of T cell defects in age-related vulnerability to West Nile virus

(2009) James D. Brien et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk

(2009) Bente K. Pedersen   JOURNAL OF PHYSIOLOGY-LONDON

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise

(2008) Richard J. Simpson et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired Dendritic Cell Function in Aging Leads to Defective Antitumor Immunity

(2008) A. Grolleau-Julius et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE

T and B lymphocyte differentiation from hematopoietic stem cell

(2008) Anne Y. Lai et al.   SEMINARS IN IMMUNOLOGY