期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 9, 页码 14883-14895出版社
WILEY
DOI: 10.1002/jcp.28318
关键词
autophagy; cancer; exercise; immunosenescence; neurodegeneration
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2016/10561-8]
- Sao Paulo Research Foundation (FAPESP) [2016/01409-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/01409-8] Funding Source: FAPESP
Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.
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