Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids

Known structures and unknown mechanisms of TMEM16 scramblases and channels

(2018) Maria E. Falzone et al.   JOURNAL OF GENERAL PHYSIOLOGY

An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase

(2018) Thomas Pelz et al.   PLoS One

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases

(2018) Arturo Medrano-Soto et al.   PLoS One

Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion

(2018) Jarred M. Whitlock et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

(2018) Byoung-Cheol Lee et al.   Nature Communications

Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila

(2018) Maria L. Sapar et al.   Cell Reports

Characterization of the scrambling domain of the TMEM16 family

(2017) Sayuri Gyobu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

(2017) Tao Jiang et al.   eLife

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

(2016) Byoung-Cheol Lee et al.   BIOPHYSICAL JOURNAL

Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion

(2016) Yu Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein species and moonlighting proteins: Very small changes in a protein's covalent structure can change its biochemical function

(2016) Constance J. Jeffery   Journal of Proteomics

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering

(2016) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

(2016) Edouard M. Bevers et al.   PHYSIOLOGICAL REVIEWS

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

(2015) Jiraporn Ousingsawat et al.   Nature Communications

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

An evolutionary perspective on protein moonlighting

(2014) Shelley D. Copley   BIOCHEMICAL SOCIETY TRANSACTIONS

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

(2014) Jason Tien et al.   eLife

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Subdued, a TMEM16 family Ca2+-activated Cl− channel in Drosophila melanogaster with an unexpected role in host defense

(2013) Xiu Ming Wong et al.   eLife

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Moonlighting proteins: An intriguing mode of multitasking

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection

(2009) S. J. F. Cronin et al.   SCIENCE

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE