N-terminal methionine excision of proteins creates tertiary destabilizing N-degrons of the Arg/N-end rule pathway

Mapping Degradation Signals and Pathways in a Eukaryotic N-terminome

(2018) Ilia Kats et al.   MOLECULAR CELL

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins

(2018) Sonya Neal et al.   MOLECULAR CELL

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway

(2018) Cheng Dong et al.   Nature Chemical Biology

N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2

(2018) Kha The Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway

(2018) Jeong-Mok Kim et al.   SCIENCE

Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway

(2017) Nico Dissmeyer et al.   NEW PHYTOLOGIST

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER–Golgi intermediate compartments

(2017) Michael G. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

(2017) Shun-Jia Chen et al.   SCIENCE

Degradation of SerotoninN-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway

(2016) Brandon Wadas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway

(2016)   MOLECULES AND CELLS

The-N-End Rule: The Beginning Determines the End

(2016) Mohamed Eldeeb et al.   PROTEIN AND PEPTIDE LETTERS

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

(2016) Frédéric Frottin et al.   Oncotarget

N-terminal protein modifications: Bringing back into play the ribosome

(2015) Carmela Giglione et al.   BIOCHIMIE

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Two N-Terminal Acetyltransferases Antagonistically Regulate the Stability of a Nod-Like Receptor in Arabidopsis

(2015) Fang Xu et al.   PLANT CELL

N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases

(2015) Petra Van Damme et al.   PROTEOMICS

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications

(2015) Jung Hoon Lee et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crosstalk between the Arg/N-end and Ac/N-end rule

(2014) Jeong-Mok Kim et al.   CELL CYCLE

The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance

(2014) Dönem Avci et al.   MOLECULAR CELL

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

High-throughput Analysis ofin vivoProtein Stability

(2013) Ikjin Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

(2013) Dimitrios Zattas et al.   MOLECULAR BIOLOGY OF THE CELL

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC

(2012) B. Lim et al.   CARCINOGENESIS

N-terminal Protein Processing: A Comparative Proteogenomic Analysis

(2012) Stefano Bonissone et al.   MOLECULAR & CELLULAR PROTEOMICS

The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+proteases

(2011) D.A. Dougan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

(2011) Francesco Licausi et al.   NATURE

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

(2011) Daniel J. Gibbs et al.   NATURE

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Dfm1 Forms Distinct Complexes with Cdc48 and the ER Ubiquitin Ligases and Is Required for ERAD

(2010) Alexandra Stolz et al.   TRAFFIC

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

(2008) Veit Goder et al.   FEBS LETTERS

Tools for analyzing and predicting N-terminal protein modifications

(2008) Thierry Meinnel et al.   PROTEOMICS