Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway

Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation inArabidopsis

(2017) Hui Dong et al.   GENES & DEVELOPMENT

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast

(2017) Sarah E. Calvo et al.   MOLECULAR & CELLULAR PROTEOMICS

Real-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes

(2017) Augustin C. Mot et al.   NEW PHYTOLOGIST

Protein Degradation Rate in Arabidopsis thaliana Leaf Growth and Development

(2017) Lei Li et al.   PLANT CELL

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

(2017) Shun-Jia Chen et al.   SCIENCE

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

(2017) Mark D. White et al.   Nature Communications

Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot

(2016) Antoine Gravot et al.   BMC PLANT BIOLOGY

Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays

(2016) Brandon Wadas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Targets and Interaction Partners of Arginyl-tRNA Protein Transferase in the MossPhyscomitrella patens

(2016) Sebastian N. W. Hoernstein et al.   MOLECULAR & CELLULAR PROTEOMICS

N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway

(2016)   MOLECULES AND CELLS

From start to finish: amino-terminal protein modifications as degradation signals in plants

(2016) Daniel J. Gibbs et al.   NEW PHYTOLOGIST

Bacterial AvrRpt2-Like Cysteine Proteases Block Activation of the Arabidopsis Mitogen-Activated Protein Kinases, MPK4 and MPK11

(2016) Lennart Eschen-Lippold et al.   PLANT PHYSIOLOGY

Phenotypes on demand via switchable target protein degradation in multicellular organisms

(2016) Frederik Faden et al.   Nature Communications

The N-end rule pathway regulates pathogen responses in plants

(2016) Rémi de Marchi et al.   Scientific Reports

Organization, function and substrates of the essential Clp protease system in plastids

(2015) Kenji Nishimura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6

(2015) Guillermina M. Mendiondo et al.   PLANT BIOTECHNOLOGY JOURNAL

Two N-Terminal Acetyltransferases Antagonistically Regulate the Stability of a Nod-Like Receptor in Arabidopsis

(2015) Fang Xu et al.   PLANT CELL

TheGreening after Extended Darkness1Is an N-End Rule Pathway Mutant with High Tolerance to Submergence and Starvation

(2015) Willi Riber et al.   PLANT PHYSIOLOGY

Quantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots

(2015) Hongtao Zhang et al.   PROTEOMICS

Proteome-wide analysis of the amino terminal status ofEscherichia coliproteins at the steady-state and upon deformylation inhibition

(2015) Willy V. Bienvenut et al.   PROTEOMICS

An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events inArabidopsis thaliana

(2015) A. Saskia Venne et al.   PROTEOMICS

Targeted Proteomics Analysis of Protein Degradation in Plant Signaling on an LTQ-Orbitrap Mass Spectrometer

(2014) Petra Majovsky et al.   JOURNAL OF PROTEOME RESEARCH

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway

(2014) Daan A. Weits et al.   Nature Communications

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

Novel Highly Sensitive, Specific, and Straightforward Strategy for Comprehensive N-Terminal Proteomics Reveals Unknown Substrates of the Mitochondrial Peptidase Icp55

(2013) A. Saskia Venne et al.   JOURNAL OF PROTEOME RESEARCH

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway

(2013) Christopher S. Brower et al.   MOLECULAR CELL

The Arabidopsis METACASPASE9 Degradome

(2013) L. Tsiatsiani et al.   PLANT CELL

ClpS1 Is a Conserved Substrate Selector for the Chloroplast Clp Protease System in Arabidopsis

(2013) K. Nishimura et al.   PLANT CELL

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

(2012) Konstantin I. Piatkov et al.   MOLECULAR CELL

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

(2012) K. I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

(2011) Daniel J. Gibbs et al.   NATURE

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

(2011) Oliver Schilling et al.   Nature Protocols

N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification

(2011) Pitter F. Huesgen et al.   PHYSIOLOGIA PLANTARUM

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

The Yeast GID Complex, a Novel Ubiquitin Ligase (E3) Involved in the Regulation of Carbohydrate Metabolism

(2008) Olivier Santt et al.   MOLECULAR BIOLOGY OF THE CELL