Treg-Centric View of Immunosuppressive Drugs in Transplantation: A Balancing Act

Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways

(2016) N. A. Zwang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

(2016) John Koreth et al.   BLOOD

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

(2016) Chong T. Luo et al.   NATURE

Isoform-Selective HDAC Inhibitor Therapy for Transplantation

(2016) Wayne W. Hancock   TRANSPLANTATION

OPTN/SRTR 2013 Annual Data Report: Heart

(2015) M. Colvin-Adams et al.   AMERICAN JOURNAL OF TRANSPLANTATION

OPTN/SRTR 2013 Annual Data Report: Kidney

(2015) A. J. Matas et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Effects of complement activation on allograft injury

(2015) Joong Hyuk Sheen et al.   Current Opinion in Organ Transplantation

Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

(2015) C. Scotta et al.   HAEMATOLOGICA

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus

(2015) Lorenzo Gallon et al.   KIDNEY INTERNATIONAL

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

(2015) Rajatava Basu et al.   NATURE IMMUNOLOGY

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

(2015) C. Scotta et al.   HAEMATOLOGICA

Depletion of Foxp3+T Cells Abrogates Tolerance of Skin and Heart Allografts in Murine Mixed Chimeras Without the Loss of Mixed Chimerism

(2014) K. Shinoda et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half-Life and Phenotype After Adoptive Transfer

(2014) K. Singh et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans

(2014) S. W. Choi et al.   BLOOD

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells

(2014) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN–Dependent Inflammatory Disease

(2014) Shivani Srivastava et al.   JOURNAL OF IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients

(2014) A. P. Bouvy et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Immunophenotyping and Efficacy of Low Dose ATG in Non-Sensitized Kidney Recipients Undergoing Early Steroid Withdrawal: A Randomized Pilot Study

(2014) Monica Grafals et al.   PLoS One

Induction of Tolerance through Mixed Chimerism

(2014) D. H. Sachs et al.   Cold Spring Harbor Perspectives in Medicine

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

(2013) Xuguang Tai et al.   IMMUNITY

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

(2013) Wing-hong Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Receptors for C3a and C5a Modulate Stability of Alloantigen-Reactive Induced Regulatory T Cells

(2013) W. van der Touw et al.   JOURNAL OF IMMUNOLOGY

Antigen-Specific Memory Regulatory CD4+Foxp3+ T Cells Control Memory Responses to Influenza Virus Infection

(2013) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Inhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans

(2013) Josh Levitsky et al.   TRANSPLANTATION

Low-Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant ArteriosclerosisIn Vivo

(2012) J. Hester et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways

(2012) Seon-Yeong Lee et al.   IMMUNOLOGY

The Development and Function of Memory Regulatory T Cells after Acute Viral Infections

(2012) A. M. Sanchez et al.   JOURNAL OF IMMUNOLOGY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

(2012) Jae-Hoon Chang et al.   NATURE IMMUNOLOGY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Methylprednisolone treatment increases the proportion of the highly suppressive HLA-DR+-Treg-cells in transplanted patients

(2012) Nicole Seissler et al.   TRANSPLANT IMMUNOLOGY

Impact of Basiliximab on the Proportion of Regulatory T Cells and Their Subsets Early After Renal Transplantation: A Preliminary Report

(2012) T. Zhao et al.   TRANSPLANTATION PROCEEDINGS

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mechanisms of Donor-Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation

(2011) G. Andreola et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mycophenolic Acid-Mediated Suppression of Human CD4+ T Cells: More Than Mere Guanine Nucleotide Deprivation

(2011) X. He et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Eculizumab treatment modifies the immune profile of PNH patients

(2011) Fiorella Alfinito et al.   IMMUNOBIOLOGY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

(2011) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Reconstitution Following Rabbit Antithymocyte Globulin

(2010) S. Gurkan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Differential requirement for CARMA1 in agonist-selected T-cell development

(2009) Benjamin D. Medoff et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Regulatory T cells overturned: the effectors fight back

(2009) Lucy S. K. Walker   IMMUNOLOGY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells

(2009) Ahmet Demirkiran et al.   TRANSPLANTATION

Calcineurin Inhibitor Withdrawal After Renal Transplantation with Alemtuzumab: Clinical Outcomes and Effect on T-Regulatory Cells

(2008) J. Pascual et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells

(2008) Christine Lagaraine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   MOLECULAR IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology