Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways

Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation

(2016) E. C. Guinan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

T-cell energy metabolism as a controller of cell fate in transplantation

(2015) Bhavana Priyadharshini et al.   Current Opinion in Organ Transplantation

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Combination treatment with perifosine and MEK-162 demonstrates synergism against lung cancer cells in vitro and in vivo

(2015) Jianli Zhang et al.   TUMOR BIOLOGY

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase

(2015) Marco Colamonici et al.   Oncotarget

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer

(2014) Leslie S. Bradford et al.   GYNECOLOGIC ONCOLOGY

Constitutive Activation of MEK1 Promotes Treg Cell Instabilityin Vivo

(2014) Jitao Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Human IL-7 Receptor   Expression by IL-7 and TCR Signaling

(2014) N. L. Alves et al.   JOURNAL OF IMMUNOLOGY

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

(2014) Samik Basu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selective Inhibition of Regulatory T Cells by Targeting the PI3K-Akt Pathway

(2014) R. Abu-Eid et al.   Cancer Immunology Research

MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells

(2014) L. J. Vella et al.   Cancer Immunology Research

Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity

(2013) Klaus Okkenhaug   Annals of the New York Academy of Sciences

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner

(2013) T. Shindo et al.   BLOOD

Cyclic AMP suppresses TGF-β-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK

(2013) Junxia Cao et al.   CELLULAR IMMUNOLOGY

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

(2013) A. Herzog et al.   CLINICAL CANCER RESEARCH

PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

(2013) Nadia Ladygina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy

(2012) J. B. Canavan et al.   BLOOD

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer

(2012) Adrian Britschgi et al.   CANCER CELL

Polar Opposites: Erk Direction of CD4 T Cell Subsets

(2012) C.-F. Chang et al.   JOURNAL OF IMMUNOLOGY

Role of MAP Kinases and PI3K-Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patients

(2012) Ana Tapia-Abellán et al.   LIVER INTERNATIONAL

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

(2012) Kazuaki Yoshioka et al.   NATURE MEDICINE

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

(2012) Dalya R. Soond et al.   Frontiers in Immunology

The Role of the PI3K Signaling Pathway in CD4+ T Cell Differentiation and Function

(2012) Jonathan M. Han et al.   Frontiers in Immunology

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

(2011) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapid assessment of in vitro expanded human regulatory T cell function

(2011) Joyce J. Ruitenberg et al.   JOURNAL OF IMMUNOLOGICAL METHODS

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells

(2011) Maria Elisabeth Kalland et al.   JOURNAL OF IMMUNOLOGY

PI3K p110  regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

(2010) D. R. Soond et al.   BLOOD

Peritoneal macrophage priming in cirrhosis is related to ERK phosphorylation and IL-6 secretion

(2010) Antonio J. Ruiz-Alcaraz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer I

(2010) Lili Xu et al.   IMMUNITY

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

(2010) Murat Cirit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

(2010) L. Lu et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells in Kidney Allograft Infiltrates Correlate With Initial Inflammation and Graft Function

(2010) Cécile Taflin et al.   TRANSPLANTATION

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

(2009) Chun-Chao Wang et al.   Molecular Systems Biology

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA