Metabolic regulation of CAR T cell function by the hypoxic microenvironment in solid tumors

T-bet promotes potent antitumor activity of CD4+ CAR T cells

(2018) Albert T Gacerez et al.   CANCER GENE THERAPY

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Driving CARs on the uneven road of antigen heterogeneity in solid tumors

(2018) Nan Chen et al.   CURRENT OPINION IN IMMUNOLOGY

Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

(2018) Fern Anari et al.   Future Oncology

Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy

(2018) Shivani Srivastava et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions

(2018) Tzu-Sheng Hsu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

(2018) Keishi Adachi et al.   NATURE BIOTECHNOLOGY

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment

(2018) Sujita Sukumaran et al.   Cancer Discovery

Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

(2018) Paris Kosti et al.   Frontiers in Immunology

CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

(2018) Pradip Bajgain et al.   Journal for ImmunoTherapy of Cancer

Lactate transporters as therapeutic targets in cancer and inflammatory diseases

(2018) Valentina Pucino et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

(2018) Hannah M. Knochelmann et al.   Frontiers in Immunology

Cancer immunologists scoop medicine Nobel prize

(2018) Heidi Ledford et al.   NATURE

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

(2017) Andras Heczey et al.   MOLECULAR THERAPY

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

Development of CAR T cells designed to improve antitumor efficacy and safety

(2017) Janneke E. Jaspers et al.   PHARMACOLOGY & THERAPEUTICS

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy

(2017) Matthias Pinter et al.   Science Translational Medicine

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

(2017) Biliang Hu et al.   Cell Reports

Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives

(2017) Zong Sheng Guo et al.   Frontiers in Immunology

Trial Watch: Adoptively transferred cells for anticancer immunotherapy

(2017) Carole Fournier et al.   OncoImmunology

IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells

(2017) Lea M. Feldhoff et al.   Scientific Reports

PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR

(2016) Elise A. Chong et al.   BLOOD

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycolysis determines dichotomous regulation of T cell subsets in hypoxia

(2016) Yang Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

(2016) Eloah Rabello Suarez et al.   Oncotarget

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression

(2016) Ying Zhang et al.   Frontiers in Immunology

Hypoxia and antitumor CD8+ T cells: An incompatible alliance?

(2016) Romain Vuillefroy de Silly et al.   OncoImmunology

Metabolism and Its Sequelae in Cancer Evolution and Therapy

(2015) Robert J. Gillies et al.   CANCER JOURNAL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity

(2015) Maarten A. Ligtenberg et al.   JOURNAL OF IMMUNOLOGY

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

HIF at a glance

(2009) M. C. Brahimi-Horn et al.   JOURNAL OF CELL SCIENCE

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY