Shared genetic architecture between metabolic traits and Alzheimer’s disease: a large-scale genome-wide cross-trait analysis

Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes

(2019) Wonil Chung et al.   Nature Communications

Genetic study of multimodal imaging Alzheimer’s disease progression score implicates novel loci

(2018) Marzia A Scelsi et al.   BRAIN

The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity—the FINGER Randomized Controlled Trial

(2018) Alessandra Marengoni et al.   Journal of the American Medical Directors Association

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

(2018) Zhaozhong Zhu et al.   NATURE GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies

(2018) Zhaozhong Zhu et al.   PLoS One

Differential associations of metabolic risk factors on cortical thickness in metabolic syndrome

(2018) Nicolette F. Schwarz et al.   NeuroImage-Clinical

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

(2018) Miia Kivipelto et al.   Nature Reviews Neurology

Investigating the genetic relationship between Alzheimer’s disease and cancer using GWAS summary statistics

(2017) Yen-Chen Anne Feng et al.   HUMAN GENETICS

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Genetic susceptibility to cardiovascular disease and risk of dementia

(2017) I K Karlsson et al.   Translational Psychiatry

Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review

(2016) Katrine Laura Rasmussen   ATHEROSCLEROSIS

Development of homogeneous assay for simultaneous measurement of apoE-deficient, apoE-containing, and total HDL-cholesterol

(2016) Yuji Takahashi et al.   CLINICA CHIMICA ACTA

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Metabolic Syndrome and Alzheimer's Disease: A Link to a Vascular Hypothesis?

(2016) Haralampos J. Milionis et al.   CNS SPECTRUMS

Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals

(2015) Thomas M. Lancaster et al.   Alzheimers & Dementia

Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension

(2015) Xiaofeng Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

(2015) Elisa Fabbri et al.   Journal of the American Medical Directors Association

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

The impact of low-frequency and rare variants on lipid levels

(2015) Ida Surakka et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

(2015) Søren D. Østergaard et al.   PLOS MEDICINE

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer

(2014) Hao Zhang et al.   World Journal of Surgical Oncology

Alzheimer’s as a metabolic disease

(2013) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

IG20/MADDPlays a Critical Role in Glucose-Induced Insulin Secretion

(2013) Liang-cheng Li et al.   DIABETES

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Glucose Levels and Risk of Dementia

(2013) Paul K. Crane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

(2012) G. Cheng et al.   INTERNAL MEDICINE JOURNAL

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

(2012) Jeroen R Huyghe et al.   NATURE GENETICS

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin

(2011) Robert Wagner et al.   PLoS One

Links between ApoE, brain cholesterol metabolism, tau and amyloid β-peptide in patients with cognitive impairment

(2010) Valerio Leoni et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Reaching the Limits of Genome-wide Significance in Alzheimer Disease

(2010) Nancy L. Pedersen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulatory mechanism of hypothalamo-pituitary–adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes

(2010) Sun Shin Yi et al.   JOURNAL OF CHEMICAL NEUROANATOMY

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers

(2009) N. Schuff et al.   BRAIN

Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in  -Cell Function

(2009) A. L. Gloyn et al.   DIABETES

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Disclosure ofAPOEGenotype for Risk of Alzheimer's Disease

(2009) Robert C. Green et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease

(2008) Giulio Maria Pasinetti et al.   JOURNAL OF NEUROCHEMISTRY