Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

(2017)   Molecular Autism

Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

(2017) A W Charney et al.   Translational Psychiatry

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia

(2016) S P Hagenaars et al.   MOLECULAR PSYCHIATRY

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

(2016) S. P. Kar et al.   Cancer Discovery

Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension

(2015) Xiaofeng Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

(2015) Yun R Li et al.   NATURE MEDICINE

What have we learned from the Psychiatric Genomics Consortium

(2015) Michael C. O'Donovan   World Psychiatry

Shared genetic aetiology of puberty timing between sexes and with health-related outcomes

(2015) Felix R. Day et al.   Nature Communications

Goodness-of-fit test for meta-analysis

(2015) Zhongxue Chen et al.   Scientific Reports

A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study

(2015) Zhongxue Chen et al.   BMC BIOINFORMATICS

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

On the optimally weighted z-test for combining probabilities from independent studies

(2013) Zhongxue Chen et al.   COMPUTATIONAL STATISTICS & DATA ANALYSIS

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Turning of COGS moves forward findings for hormonally mediated cancers

(2013) Lori C Sakoda et al.   NATURE GENETICS

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

(2012) Samsiddhi Bhattacharjee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comprehensive literature review and statistical considerations for GWAS meta-analysis

(2012) Ferdouse Begum et al.   NUCLEIC ACIDS RESEARCH

Interpreting Meta-Analyses of Genome-Wide Association Studies

(2012) Buhm Han et al.   PLoS Genetics

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

(2011) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework

(2011) Phil H. Lee et al.   HUMAN HEREDITY

Is the weighted z-test the best method for combining probabilities from independent tests?

(2011) Z. CHEN   JOURNAL OF EVOLUTIONARY BIOLOGY

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

P-value based analysis for shared controls design in genome-wide association studies

(2010) Dmitri V. Zaykin et al.   GENETIC EPIDEMIOLOGY

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

(2010) Kai Wang et al.   HUMAN MOLECULAR GENETICS