Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling

(2014) N. S. Woodling et al.   JOURNAL OF NEUROSCIENCE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia

(2013) J. U. Johansson et al.   JOURNAL OF NEUROSCIENCE

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

(2013) Gary P. Morris et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Response to Comments on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) G. E. Landreth et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Inflammatory prostaglandin E2signaling in a mouse model of Alzheimer disease

(2012) Ju Shi et al.   ANNALS OF NEUROLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

β-Catenin–dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells

(2012) Jinbo Han et al.   MOLECULAR BIOLOGY OF THE CELL

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

(2011) Charles Y. Shao et al.   ACTA NEUROPATHOLOGICA

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease

(2011) Gehua Zhen et al.   NEUROBIOLOGY OF AGING

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E2 Receptor Subtype 2-Null Bone Marrow

(2010) C. Dirk Keene et al.   AMERICAN JOURNAL OF PATHOLOGY

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

(2009) C. D. Clelland et al.   SCIENCE

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

(2008) Tao Yang et al.   PLoS One