Broad-spectrum coronavirus antiviral drug discovery

Human Coronaviruses and other Respiratory Infections in Young Adults on a University Campus: Prevalence, Symptoms, and Shedding

(2018) Brian M. Davis et al.   Influenza and Other Respiratory Viruses

Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis

(2018) Mostafa Ebraheem Morra et al.   REVIEWS IN MEDICAL VIROLOGY

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

(2018) Yaseen M. Arabi et al.   Trials

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice

(2018) Adam S. Cockrell et al.   MAMMALIAN GENOME

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

(2017) François Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

(2017) Kun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

(2017) Adriaan H. de Wilde et al.   VIRUS RESEARCH

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

(2017) S. J. Anthony et al.   mBio

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

(2017) Vineet D. Menachery et al.   mBio

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene

(2016) Liang Shen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Taking forward a ‘One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential

(2016) Alimuddin Zumla et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

(2016) Nan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

(2016) Katherine V. Houser et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

(2016) Reed F. Johnson et al.   VIROLOGY

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

(2016) Adam S. Cockrell et al.   Nature Microbiology

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report

(2015) Uh Jin Kim et al.   ANTIVIRAL THERAPY

Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea

(2015) Seo Yu Bin et al.   CLINICAL INFECTIOUS DISEASES

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

(2015) Kun Li et al.   JOURNAL OF INFECTIOUS DISEASES

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

(2015) Bart L. Haagmans et al.   JOURNAL OF VIROLOGY

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study

(2015) Marcel A Müller et al.   LANCET INFECTIOUS DISEASES

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus

(2015) Troy C. Sutton et al.   VIROLOGY

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

(2015) Reed F. Johnson et al.   VIROLOGY

MERS coronavirus: diagnostics, epidemiology and transmission

(2015) Ian M. Mackay et al.   Virology Journal

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(2015) Lisa E. Gralinski et al.   PLoS Genetics

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26

(2014) Qihui Wang et al.   Cell Host & Microbe

Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness

(2014) J. Sui et al.   JOURNAL OF VIROLOGY

Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay

(2014) H. A. Elshabrawy et al.   JOURNAL OF VIROLOGY

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

(2014) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

(2014) S. Agnihothram et al.   mBio

Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

(2014) A. N. Alagaili et al.   mBio

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

(2014) Darryl Falzarano et al.   PLoS Pathogens

Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study

(2014) Renee W Y Chan et al.   Lancet Respiratory Medicine

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

(2013) Jan Felix Drexler et al.   ANTIVIRAL RESEARCH

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

(2013) C. M. Coleman et al.   JOURNAL OF GENERAL VIROLOGY

Interferon-  and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

(2013) B. J. Hart et al.   JOURNAL OF GENERAL VIROLOGY

Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses

(2013) Sudhakar Agnihothram et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC/2012: Implications for Disease Pathogenesis and Clinical Manifestation

(2013) Jasper Fuk-Woo Chan, Kwok-Hung Chan, Garnet Kwan-Yue Choi, Kelvin Kai-Wang To, Herman Tse, Jian-Piao Cai et al.   JOURNAL OF INFECTIOUS DISEASES

Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

(2013) V. S. Raj et al.   JOURNAL OF VIROLOGY

Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell Tropism

(2013) R. Dijkman et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

(2013) Darryl Falzarano et al.   NATURE MEDICINE

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters

(2013) Emmie de Wit et al.   PLoS One

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

(2013) E. de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

(2013) T. Scobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atlas of coronavirus replicase structure

(2013) Benjamin W. Neuman et al.   VIRUS RESEARCH

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

(2013) L. E. Gralinski et al.   mBio

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

(2013) Darryl Falzarano et al.   Scientific Reports

Intranasal Treatment with Poly(I{middle dot}C) Protects Aged Mice from Lethal Respiratory Virus Infections

(2012) J. Zhao et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Distinct Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Pathways in Two Different Nonhuman Primate Species

(2011) S. L. Smits et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques

(2011) Barry Rockx et al.   PLoS One

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

(2010) T. Sheahan et al.   JOURNAL OF VIROLOGY

Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures

(2010) K. Pyrc et al.   JOURNAL OF VIROLOGY

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

(2009) Craig W. Day et al.   VIROLOGY

High-throughput assay using a GFP-expressing replicon for SARS-CoV drug discovery

(2008) F GE et al.   ANTIVIRAL RESEARCH

Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a model

(2008) Bridget S. Banach et al.   JOURNAL OF VIROLOGICAL METHODS

Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus

(2008) T. Sheahan et al.   JOURNAL OF VIROLOGY

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

(2008) M. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA