Journal
TOXINS
Volume 5, Issue 6, Pages 1180-1201Publisher
MDPI AG
DOI: 10.3390/toxins5061180
Keywords
HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma
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Funding
- Italian Association for Cancer Research (AIRC, Milan, Italy)/Cariverona Foundation (Verona, Italy)
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Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment.
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