Bone morphogenetic protein signaling in inflammation

Calcification Induced by Type I Interferon in Human Aortic Valve Interstitial Cells Is Larger in Males and Blunted by a Janus Kinase Inhibitor

(2018) Iván Parra-Izquierdo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and fibrosis

(2018) Matthias Mack   MATRIX BIOLOGY

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

(2018) Yan Li et al.   Nature Reviews Cardiology

DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

(2018) Diana Carvalho et al.   NEURO-ONCOLOGY

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling

(2018) Carine Fillebeen et al.   BLOOD

ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2

(2018) Lisa Traeger et al.   FREE RADICAL BIOLOGY AND MEDICINE

BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation

(2018) Evangelia Pardali et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-fibrotic effects of bone morphogenetic protein-7-modified bone marrow mesenchymal stem cells on silica-induced pulmonary fibrosis

(2017) Xiaoli Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

The biophysics, biochemistry and physiology of CFTR

(2016) Oscar Moran   CELLULAR AND MOLECULAR LIFE SCIENCES

BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway

(2016) Di Liang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial InfarctionNovelty and Significance

(2016) Lehanna N. Sanders et al.   CIRCULATION RESEARCH

Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function

(2016) Thomas Helbing et al.   INFLAMMATION

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism

(2016) Kristof Nolan et al.   Cell Reports

Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells

(2015) Lai-Ming Yung et al.   CARDIOVASCULAR RESEARCH

Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells

(2015) Partha Dutta et al.   Cell Stem Cell

Genetic analysis of Runx2 function during intramembranous ossification

(2015) Takeshi Takarada et al.   DEVELOPMENT

When endothelial cells go rogue

(2015) P.-Y. Chen et al.   EMBO Molecular Medicine

Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?

(2015) Matthias Nahrendorf et al.   EUROPEAN HEART JOURNAL

Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes

(2015) Alberto Varas et al.   ARTHRITIS RESEARCH & THERAPY

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

(2014) Nermi L. Parrow et al.   Annual Review of Nutrition

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

(2014) C. Mayeur et al.   BLOOD

Cardiac macrophages and their role in ischaemic heart disease

(2014) Stefan Frantz et al.   CARDIOVASCULAR RESEARCH

Inhibition of BMP signaling suppresses metastasis in mammary cancer

(2014) P Owens et al.   ONCOGENE

The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice

(2013) Mitsuhisa Koga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

BMP signaling in development and diseases: A pharmacological perspective

(2013) Amitabha Bandyopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

A Role for the Endothelium in Vascular Calcification

(2013) Yucheng Yao et al.   CIRCULATION RESEARCH

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

(2013) Yasmine Zouggari et al.   NATURE MEDICINE

Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism

(2013) Kristof Nolan et al.   STRUCTURE

Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats

(2013) Gengxia Yang et al.   TOXICOLOGY LETTERS

IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes

(2012) Arnaud Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bmper Inhibits Endothelial Expression of Inflammatory Adhesion Molecules and Protects Against Atherosclerosis

(2012) Xinchun Pi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation

(2012) Emma de Pater et al.   CIRCULATION RESEARCH

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

(2012) I. I. Muller et al.   Disease Models & Mechanisms

Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers

(2012) Chandramohan Kattamuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium

(2011) T. Helbing et al.   BLOOD

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

(2011) Craig A. Harrison et al.   GROWTH FACTORS

IL-17A- versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes

(2010) A. Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Bone Morphogenetic Proteins Protects Against Atherosclerosis and Vascular Calcification

(2010) Yucheng Yao et al.   CIRCULATION RESEARCH

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bmp Signaling Regulates Myocardial Differentiation from Cardiac Progenitors Through a MicroRNA-Mediated Mechanism

(2010) Jun Wang et al.   DEVELOPMENTAL CELL

Mechanistic connection between inflammation and fibrosis

(2010) Soo Bong Lee et al.   KIDNEY INTERNATIONAL

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

(2009) Jijun Hao et al.   ACS Chemical Biology

BMP4 regulates the hematopoietic stem cell niche

(2009) D. C. Goldman et al.   BLOOD

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells

(2008) Xianwu Li et al.   ATHEROSCLEROSIS

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Two novel type II receptors mediate BMP signalling and are required to establish left–right asymmetry in zebrafish

(2008) Rui Monteiro et al.   DEVELOPMENTAL BIOLOGY

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

(2008) David J. McCulley et al.   DEVELOPMENTAL DYNAMICS

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4

(2008) M. B. Furtado et al.   GENES & DEVELOPMENT

Smad7 Is Required for the Development and Function of the Heart

(2008) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Myocardial Infarct Proteins and Oscillating Pressure on the Differentiation of Mesenchymal Stem Cells: Effect of Acute Myocardial Infarction on Stem Cell Differentiation

(2008) Sung-A Chang et al.   STEM CELLS