Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels

Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models

(2016) Juan A. Contreras-Vite et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Study of permeation and blocker binding in TMEM16A calcium-activated chloride channels

(2015) JP Reyes et al.   Channels

Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)

(2015) Amelia Mazzone et al.   FASEB JOURNAL

Pharmacological properties of native CaCCs and TMEM16A

(2014) Kenton M Sanders et al.   Channels

Pharmacological characterization of TMEM16A currents

(2014) Eamonn Bradley et al.   Channels

Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation

(2014) Anke Bill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

(2014) Kuai Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel

(2014) Yawei Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ano1, a Ca2+-activated Cl−channel, coordinates contractility in mouse intestine by Ca2+transient coordination between interstitial cells of Cajal

(2014) Raman Deep Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels

(2013) Kerstin Vocke et al.   JOURNAL OF GENERAL PHYSIOLOGY

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01

(2012) Alison J Davis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A minimal isoform of the TMEM16A protein associated with chloride channel activity

(2011) Loretta Ferrera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing

(2011) Kate E O'Driscoll et al.   BMC MOLECULAR BIOLOGY

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis

(2011) Amelia Mazzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscarinic activation of Ca2+-activated Cl−current in interstitial cells of Cajal

(2011) Mei Hong Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interaction of Bestrophin-1 and Ca2+ Channel β-Subunits: Identification of New Binding Domains on the Bestrophin-1 C-Terminus

(2011) Vladimir M. Milenkovic et al.   PLoS One

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

(2010) Yuemin Tian et al.   FASEB JOURNAL

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

(2009) Jiraporn Ousingsawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+-activated Cl−conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

(2009) Mei Hong Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

(2009) Sung Jin Hwang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Expression of TMEM16 paralogs during murine embryogenesis

(2008) Jason R. Rock et al.   DEVELOPMENTAL DYNAMICS

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE