Biogenesis and secretion of micronemes in Toxoplasma gondii

A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis

(2018) Juliette Morlon-Guyot et al.   CELLULAR MICROBIOLOGY

A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation

(2018) Mayumi Tachibana et al.   CELLULAR MICROBIOLOGY

The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis

(2018) Stéphanie Hallée et al.   CELLULAR MICROBIOLOGY

Phosphoinositides and their functions in apicomplexan parasites

(2018) Kai Wengelnik et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

SECRETORY ORGANELLE TRAFFICKING IN TOXOPLASMA GONDII : A LONG STORY FOR A SHORT TRAVEL

(2018) Kannan Venugopal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis

(2018) Pierre-Mehdi Hammoudi et al.   MOLECULAR MICROBIOLOGY

SNARE complex in axonal guidance and neuroregeneration

(2018) SofiaJ Araújo et al.   Neural Regeneration Research

Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites

(2018) Nick Darvill et al.   STRUCTURE

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

(2018) James A. Thomas et al.   Nature Microbiology

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase

(2018) Kevin M. Brown et al.   Cell Host & Microbe

A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion

(2018) Bradley I. Coleman et al.   mBio

Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii

(2017) Jacqueline M. Leung et al.   MOLECULAR BIOLOGY OF THE CELL

A tethering complex drives the terminal stage of SNARE-dependent membrane fusion

(2017) Massimo D’Agostino et al.   NATURE

Phosphatidylinositol (4, 5)-bisphosphate targets double C2 domain protein B to the plasma membrane

(2017) Lirin Michaeli et al.   TRAFFIC

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

(2017) Kevin M. Brown et al.   mBio

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

(2017) Karine Frénal et al.   Nature Communications

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division

(2017) Kannan Venugopal et al.   PLoS Pathogens

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

(2017) Sunil Kumar Dogga et al.   eLife

Two Phosphoglucomutase Paralogs Facilitate Ionophore-Triggered Secretion of the Toxoplasma Micronemes

(2017) Sudeshna Saha et al.   mSphere

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma

(2016) Hayley E. Bullen et al.   Cell Host & Microbe

A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa

(2016) Hayley E. Bullen et al.   FEBS LETTERS

Trichocysts-Paramecium'sProjectile-like Secretory Organelles

(2016) Helmut Plattner   JOURNAL OF EUKARYOTIC MICROBIOLOGY

C2-domain containing calcium sensors in neuroendocrine secretion

(2016) Paulo S. Pinheiro et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Analysis of thePlasmodium bergheiGametocyte Egressome and Vesicular bioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP) as an Essential Factor for Parasite Transmission

(2016) Jessica Kehrer et al.   MOLECULAR & CELLULAR PROTEOMICS

Calcium signalling in malaria parasites

(2016) Mathieu Brochet et al.   MOLECULAR MICROBIOLOGY

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection

(2016) Lamba Omar Sangaré et al.   Nature Communications

A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility

(2016) Jessica Kehrer et al.   PLoS Pathogens

A Critical Role for Toxoplasma gondii Vacuolar Protein Sorting VPS9 in Secretory Organelle Biogenesis and Host Infection

(2016) Takaya Sakura et al.   Scientific Reports

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

(2015) Sebastian Lourido et al.   CELL CALCIUM

Toxoplasma gondiiVps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles

(2015) Juliette Morlon-Guyot et al.   CELLULAR MICROBIOLOGY

The apicomplexan glideosome and adhesins – Structures and function

(2015) Lauren E. Boucher et al.   JOURNAL OF STRUCTURAL BIOLOGY

Distinct properties of the egress-related osmiophilic bodies in male and female gametocytes of the rodent malaria parasitePlasmodium berghei

(2014) Anna Olivieri et al.   CELLULAR MICROBIOLOGY

SNARE-ing the structures of Sec1/Munc18 proteins

(2014) Julia K Archbold et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium when associated with membranes

(2014) Sophonie Jean et al.   EXPERIMENTAL PARASITOLOGY

Functional architecture of MFS D-glucose transporters

(2014) M. G. Madej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion

(2014) B. Shen et al.   mBio

Plasticity and redundancy among AMA–RON pairs ensure host cell entry of Toxoplasma parasites

(2014) Mauld H. Lamarque et al.   Nature Communications

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The Apical Complex Provides a Regulated Gateway for Secretion of Invasion Factors in Toxoplasma

(2014) Nicholas J. Katris et al.   PLoS Pathogens

The Toxoplasma Protein ARO Mediates the Apical Positioning of Rhoptry Organelles, a Prerequisite for Host Cell Invasion

(2013) Christina Mueller et al.   Cell Host & Microbe

A perforin-like protein mediates disruption of the erythrocyte membrane during egress ofPlasmodium bergheimale gametocytes

(2013) Elena Deligianni et al.   CELLULAR MICROBIOLOGY

A Key Role forPlasmodiumSubtilisin-like SUB1 Protease in Egress of Malaria Parasites from Host Hepatocytes

(2013) Lina Tawk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion

(2013) Daniel Y. Bargieri et al.   Nature Communications

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes

(2013) Katrin Kremer et al.   PLoS Pathogens

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection

(2012) Pierre-Julien Sloves et al.   Cell Host & Microbe

Dynein light chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth

(2012) Bilal M. Qureshi et al.   FASEB JOURNAL

Evolution of apicomplexan secretory organelles

(2012) Marc-Jan Gubbels et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The SNARE complex in neuronal and sensory cells

(2012) Neeliyath A. Ramakrishnan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis

(2012) A. Farrell et al.   SCIENCE

The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

(2011) Moritz Treeck et al.   Cell Host & Microbe

RNAi knockdown of parafusin inhibits the secretory pathway

(2011) Li Liu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Dynamics and 3D organization of secretory organelles of Toxoplasma gondii

(2011) Tatiana Christina Paredes-Santos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Conditional Peripheral Membrane Proteins: Facing up to Limited Specificity

(2011) Katarina Moravcevic et al.   STRUCTURE

Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane Repair

(2011) Angela Lek et al.   TRAFFIC

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites

(2010) Vanessa Lagal et al.   CELLULAR MICROBIOLOGY

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii

(2010) Fabiola Parussini et al.   MOLECULAR MICROBIOLOGY

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

The Vps10p-domain receptor family

(2009) Guido Hermey   CELLULAR AND MOLECULAR LIFE SCIENCES

Induction and regulation of conoid extrusion inToxoplasma gondii

(2009) M. González Del Carmen et al.   CELLULAR MICROBIOLOGY

A Dynamin Is Required for the Biogenesis of Secretory Organelles in Toxoplasma gondii

(2009) Manuela S. Breinich et al.   CURRENT BIOLOGY

The role played by electron microscopy in advancing our understanding of Toxoplasma gondii and other apicomplexans

(2009) Jean François Dubremetz et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

Microneme protein 8 - a new essential invasion factor in Toxoplasma gondii

(2008) H. Kessler et al.   JOURNAL OF CELL SCIENCE

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

(2008) B. F. C. Kafsack et al.   SCIENCE

Kiss and spit: the dual roles of Toxoplasma rhoptries

(2007) John C. Boothroyd et al.   NATURE REVIEWS MICROBIOLOGY