期刊
CELLULAR MICROBIOLOGY
卷 21, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/cmi.13018
关键词
Apicomplexa; exocytosis; invasion; membranous fusion; microneme; Plasmodium; secretory organelles; signalling; Toxoplasma gondii
资金
- European Research Council (ERC) [695596]
- Swiss National Science Foundation [FN3100A0-116722]
- European Research Council (ERC) [695596] Funding Source: European Research Council (ERC)
One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly specialised, apical secretory organelles, called the micronemes and rhoptries that play critical roles in ensuring survival and dissemination. Upon exocytosis, the micronemes release adhesin complexes, perforins, and proteases that are crucially implicated in egress from infected cells, gliding motility, migration across biological barriers, and host cell invasion. Recent studies on Toxoplasma gondii and Plasmodium species have shed more light on the signalling events and the machinery that trigger microneme secretion. Intracellular cyclic nucleotides, calcium level, and phosphatidic acid act as key mediators of microneme exocytosis, and several downstream effectors have been identified. Here, we review the key steps of microneme biogenesis and exocytosis, summarising the still fractal knowledge at the molecular level regarding the fusion event with the parasite plasma membrane.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据