Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 48, Issue 7, Pages 493-504Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2018.01.009
Keywords
Malaria; Plasmodium; Toxoplasma gondii; Lipid; Phosphoinositide; Drug target; Lipid kinase; Lipid phosphatase
Categories
Funding
- Agence Nationale de la Recherche, France (APICO-PIP) [ANR-11-BSV3-015-01]
- Laboratoire d'Excellence (LabEx), France [ANR-11-LABX-0024]
- Fondation pour la Recherche Medicate, France [FRM DEQ20130326508]
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Phosphoinositides are the phosphorylated derivatives of the structural membrane phospholipid phosphatidylinositol. Single or combined phosphorylation at the 3, 4 and 5 positions of the inositol ring gives rise to the seven different species of phosphoinositides. All are quantitatively minor components of cellular membranes but have been shown to have important functions in multiple cellular processes. Here we describe our current knowledge of phosphoinositide metabolism and functions in apicomplexan parasites, mainly focusing on Toxoplasma gondii and Plasmodium spp. Even though our understanding is still rudimentary, phosphoinositides have already shown their importance in parasite biology and revealed some very particular and parasite-specific functions. Not surprisingly, there is a strong potential for phosphoinositide synthesis to be exploited for future anti-parasitic drug development. (C) 2018 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
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