The innate immune response to allotransplants: mechanisms and therapeutic potentials

A phase I/II, double-blind, placebo-controlled study assessing safety and efficacy of C1 esterase inhibitor for prevention of delayed graft function in deceased donor kidney transplant recipients

(2018) Stanley C. Jordan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

α 1 -Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion

(2018) Huiqing Lin et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection

(2018) Grecia M. Marrón-Liñares et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Navigating T-Cell Immunometabolism in Transplantation

(2018) Naoki Tanimine et al.   TRANSPLANTATION

Altered Cellular Metabolism Drives Trained Immunity

(2018) Yahya Sohrabi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

Immunological consequences of kidney cell death

(2018) Maysa Sarhan et al.   Cell Death & Disease

Regulation of the Immune Response by the Inflammatory Metabolic Microenvironment in the Context of Allotransplantation

(2018) Nicolas Degauque et al.   Frontiers in Immunology

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model

(2017) Tiago N. Machuca et al.   HUMAN GENE THERAPY

TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement

(2017) Joong-Hyuk Sheen et al.   JOURNAL OF IMMUNOLOGY

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Human α1-antitrypsin improves early post-transplant lung function: Pre-clinical studies in a pig lung transplant model

(2016) Ilker Iskender et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Diagnosis of complement alternative pathway disorders

(2016) Andrea Angioi et al.   KIDNEY INTERNATIONAL

Role of TLRs and DAMPs in allograft inflammation and transplant outcomes

(2016) Faouzi Braza et al.   Nature Reviews Nephrology

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Xenon Treatment Protects against Remote Lung Injury after Kidney Transplantation in Rats

(2015) Hailin Zhao et al.   ANESTHESIOLOGY

Molecules Great and Small: The Complement System

(2015) D. R. Mathern et al.   Clinical Journal of the American Society of Nephrology

Suppression of antigen presentation by IL-10

(2015) Sharad K Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance

(2015) Patricia Conde et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

The Lectin Pathway of Complement and Rheumatic Heart Disease

(2015) Marcia Holsbach Beltrame et al.   Frontiers in Pediatrics

HMGB1 Is Involved in Chronic Rejection of Cardiac Allograft via Promoting Inflammatory-Like mDCs

(2014) H. Zou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Non-self recognition by monocytes initiates allograft rejection

(2014) Martin H. Oberbarnscheidt et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

An update on ABO-incompatible kidney transplantation

(2014) Stefan Zschiedrich et al.   TRANSPLANT INTERNATIONAL

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats

(2013) H. Zhao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The use of eculizumab in renal transplantation

(2013) A. Nicholas R. Barnett et al.   CLINICAL TRANSPLANTATION

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibody-mediated rejection, T cell–mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies

(2013) Philip F. Halloran et al.   KIDNEY INTERNATIONAL

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Toll-like receptors in transplantation: sensing and reacting to injury

(2012) Jeremy S. Leventhal et al.   KIDNEY INTERNATIONAL

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

The role of complement in antibody-mediated rejection in kidney transplantation

(2012) Mark D. Stegall et al.   Nature Reviews Nephrology

Adenosine A 2A Agonist Improves Lung Function During Ex Vivo Lung Perfusion

(2011) Abbas Emaminia et al.   ANNALS OF THORACIC SURGERY

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation

(2011) Marcelo Cypel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic eculizumab prior to kidney transplantation for atypical hemolytic uremic syndrome

(2011) Marcus Weitz et al.   PEDIATRIC NEPHROLOGY

Organ Preservation: Current Concepts and New Strategies for the Next Decade

(2011) Edgardo E. Guibert et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Complement halts angiogenesis gone wild

(2010) W. H. A. Kahr   BLOOD

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

The complement system

(2010) J. Vidya Sarma et al.   CELL AND TISSUE RESEARCH

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

(2010) Li Wu   IMMUNITY

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

(2010) Mercedes Rodriguez Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4

(2010) Adam G Testro et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

TLR2 and TLR4 in Ischemia Reperfusion Injury

(2010) F. Arslan et al.   MEDIATORS OF INFLAMMATION

Neutralization of the extracellular HMGB1 released by ischaemic-damaged renal cells protects against renal ischaemia-reperfusion injury

(2010) J. Li et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Protective Effects of Toll-like Receptor 4 Inhibitor Eritoran on Renal Ischemia-Reperfusion Injury

(2010) M. Liu et al.   TRANSPLANTATION PROCEEDINGS

Toll-like receptor signaling in transplantation

(2009) Maria-Luisa Alegre et al.   Current Opinion in Organ Transplantation

Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling

(2009) S. Wang et al.   Disease Models & Mechanisms

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Repair of Human Donor Lungs by IL-10 Gene Therapy

(2009) M. Cypel et al.   Science Translational Medicine

Contrasted Blood and Intragraft Toll-Like Receptor 4 mRNA Profiles in Operational Tolerance Versus Chronic Rejection in Kidney Transplant Recipients

(2009) Cécile Braudeau et al.   TRANSPLANTATION

Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury

(2008) Xiufen Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

De novo autoimmunity after organ transplantation: Targets and possible pathways

(2008) Peter Boros et al.   HUMAN IMMUNOLOGY

Should Complement Activation Be a Target for Therapy in Renal Transplantation?

(2008) N. S. Sheerin   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement 5a Receptor Inhibition Improves Renal Allograft Survival

(2008) F. Gueler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

(2008) Wilco P. Pulskens et al.   PLoS One

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY

Toll-like Receptor Expression in Patients With Renal Allograft Dysfunction

(2008) J. Kwon et al.   TRANSPLANTATION PROCEEDINGS