Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance

Isotype dependent on-column non-reversible aggregation of monoclonal antibodies

(2018) Monika Farys et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biopharmaceutical benchmarks 2018

(2018) Gary Walsh   NATURE BIOTECHNOLOGY

Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material

(2016) Saloumeh Kadkhodayan Fischer et al.   AAPS Journal

Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody

(2016) Cyrus D. Agarabi et al.   BIOTECHNOLOGY PROGRESS

Ultra scale-down approaches to enhance the creation of bioprocesses at scale: impacts of process shear stress and early recovery stages

(2016) Andrea CME Rayat et al.   Current Opinion in Chemical Engineering

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control

(2015) Daniel G. Bracewell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

(2015) Jared S. Bee et al.   BIOTECHNOLOGY PROGRESS

Unfolding and aggregation of monoclonal antibodies on cation exchange columns: Effects of resin type, load buffer, and protein stability

(2015) Jing Guo et al.   JOURNAL OF CHROMATOGRAPHY A

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold

(2015) Alice R. Mazzer et al.   JOURNAL OF CHROMATOGRAPHY A

CHOPPI: A web tool for the analysis of immunogenicity risk from host cell proteins in CHO-based protein production

(2014) Chris Bailey-Kellogg et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies

(2014) Nabila Aboulaich et al.   BIOTECHNOLOGY PROGRESS

Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

(2014) Catherine EM Hogwood et al.   CURRENT OPINION IN BIOTECHNOLOGY

Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry

(2014) Qingchun Zhang et al.   mAbs

Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

(2013) Nicholas E. Levy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography

(2012) Vikram N. Sisodiya et al.   Biotechnology Journal

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

(2011) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Select host cell proteins coelute with monoclonal antibodies in protein a chromatography

(2011) Bartek Nogal et al.   BIOTECHNOLOGY PROGRESS

Advances in the production and downstream processing of antibodies

(2011) John H. Chon et al.   New Biotechnology

Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity

(2010) Sharon X. Gao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Ultra scale-down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths

(2009) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Degradation of an Fc-fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease

(2009) Flavie Robert et al.   BIOTECHNOLOGY AND BIOENGINEERING

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

(2009) Mi Jin et al.   BIOTECHNOLOGY AND BIOENGINEERING