Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells

(2011) Min Kyoung Jeon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

(2011) Paula Meleady et al.   BMC BIOTECHNOLOGY

Process analytical technology (PAT) for biopharmaceutical products

(2010) A. S. Rathore et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Improved process analytical technology for protein a chromatography using predictive principal component analysis tools

(2010) Ying Hou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid whole monoclonal antibody analysis by mass spectrometry: An Ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile

(2010) C.Q. Reid et al.   BIOTECHNOLOGY AND BIOENGINEERING

PAT method to gather bioprocess parameters in real-time using simple input variables and first principle relationships

(2010) Patrick Wechselberger et al.   CHEMICAL ENGINEERING SCIENCE

Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody

(2010) Julita K. Grzeskowiak et al.   ELECTROPHORESIS

Recent advances in large-scale production of monoclonal antibodies and related proteins

(2010) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Ultra scale-down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths

(2009) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

The isolation and identification of a secreted biomarker associated with cell stress in serum-free CHO cell culture

(2009) John F. Woolley et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell proteins in biologics development: Identification, quantitation and risk assessment

(2009) Xing Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

(2009) Mi Jin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Product and contaminant measurement in bioprocess development by SELDI-MS

(2009) Alex Berrill et al.   BIOTECHNOLOGY PROGRESS

Separation of product associatingE. colihost cell proteins OppA and DppA from recombinant apolipoprotein A-IMilanoin an industrial HIC unit operation

(2009) Alan K. Hunter et al.   BIOTECHNOLOGY PROGRESS

Expression systems for therapeutic glycoprotein production

(2009) Yves Durocher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Guidelines to cell engineering for monoclonal antibody production

(2009) A. Rita Costa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Use of proteomics for design of a tailored host cell for highly efficient protein purification

(2009) Zhu Liu et al.   JOURNAL OF CHROMATOGRAPHY A

2-D DIGE to expedite downstream process development for human monoclonal antibody purification

(2009) Julita K. Grzeskowiak et al.   PROTEIN EXPRESSION AND PURIFICATION

Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion

(2009) E-ri M Sol et al.   Proteome Science

The application of SELDI-TOF mass spectrometry to mammalian cell culture

(2008) John F. Woolley et al.   BIOTECHNOLOGY ADVANCES

Demonstration of Robust Host Cell Protein Clearance in Biopharmaceutical Downstream Processes

(2008) A.A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Applications of SELDI-MS technology in oncology

(2008) L. C. Whelan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol

(2008) Paula Meleady et al.   PROTEOMICS

Proteomic Profiling of Secreted Proteins from CHO Cells Using Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry

(2007) N. Kumar et al.   BIOTECHNOLOGY PROGRESS

Optimized Removal of Soluble Host Cell Proteins for the Recovery of met-Human Growth Hormone Inclusion Bodies from Escherichia coli Cell Lysate Using Crossflow Microfiltration

(2007) Adith Venkiteshwaran et al.   BIOTECHNOLOGY PROGRESS