Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

Host cell protein analysis in therapeutic protein bioprocessing - methods and applications

(2013) Anne Luise Tscheliessnig et al.   Biotechnology Journal

Multi-dimensional fractionation and characterization of crude protein mixtures: Toward establishment of a database of protein purification process development parameters

(2012) Beckley K. Nfor et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein adsorption characteristics during protein a chromatography

(2012) Richard D. R. Tarrant et al.   BIOTECHNOLOGY PROGRESS

Optimization of protein sample preparation for two-dimensional electrophoresis

(2012) Kristin N. Valente et al.   ELECTROPHORESIS

Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

(2012) Catalin Doneanu et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

(2011) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Select host cell proteins coelute with monoclonal antibodies in protein a chromatography

(2011) Bartek Nogal et al.   BIOTECHNOLOGY PROGRESS

Process Development and Design of Downstream Processes

(2011) Jochen Strube et al.   CHEMIE INGENIEUR TECHNIK

Separation science is the key to successful biopharmaceuticals

(2011) Georges Guiochon et al.   JOURNAL OF CHROMATOGRAPHY A

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

Research and development of next generation of antibody-based therapeutics

(2010) Jing Li et al.   ACTA PHARMACOLOGICA SINICA

Interactions and phase behavior of a monoclonal antibody

(2010) Rachael A. Lewus et al.   BIOTECHNOLOGY PROGRESS

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Recent advances in large-scale production of monoclonal antibodies and related proteins

(2010) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

(2009) Mi Jin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evicting hitchhiker antigens from purified antibodies

(2009) Keith A. Luhrs et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Bioseparation in Antibody Manufacturing: The Good, The Bad and The Ugly

(2008) U. Gottschalk   BIOTECHNOLOGY PROGRESS

Host cell protein clearance during protein a chromatography: Development of an improved column wash step

(2008) Abhinav A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Salting-Out of Lysozyme and Ovalbumin from Mixtures: Predicting Precipitation Performance from Protein−Protein Interactions

(2008) Yu-Chia Cheng et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Proteomic Profiling of Secreted Proteins from CHO Cells Using Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry

(2007) N. Kumar et al.   BIOTECHNOLOGY PROGRESS