Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing

(2015) Kristin N. Valente et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies

(2014) Nabila Aboulaich et al.   BIOTECHNOLOGY PROGRESS

Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

(2014) Srivalli N. Telikepalli et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Ester Hydrolysis of Polysorbate 80 in mAb Drug Product: Evidence in Support of the Hypothesized Risk After the Observation of Visible Particulate in mAb Formulations

(2014) Steven R. Labrenz   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of Residual Impurities and Contaminants on Protein Stability

(2014) Wei Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry

(2014) Qingchun Zhang et al.   mAbs

Improved detection of host cell proteins (HCPs) in a mammalian cell-derived antibody drug using liquid chromatography/mass spectrometry in conjunction with an HCP-enrichment strategy

(2014) Jenny Heidbrink Thompson et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

(2013) Nicholas E. Levy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Profiling the effects of process changes on residual host cell proteins in biotherapeutics by mass spectrometry

(2013) Matthew R. Schenauer et al.   BIOTECHNOLOGY PROGRESS

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

(2013) Nathan E Lewis et al.   NATURE BIOTECHNOLOGY

Caprylic acid precipitation method for impurity reduction: An alternative to conventional chromatography for monoclonal antibody purification

(2012) Yan Brodsky et al.   BIOTECHNOLOGY AND BIOENGINEERING

Immunogenicity of protein aggregates—Concerns and realities

(2012) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Proteomic Analysis of Chinese Hamster Ovary Cells

(2012) Deniz Baycin-Hizal et al.   JOURNAL OF PROTEOME RESEARCH

Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

(2012) Catalin Doneanu et al.   mAbs

Select host cell proteins coelute with monoclonal antibodies in protein a chromatography

(2011) Bartek Nogal et al.   BIOTECHNOLOGY PROGRESS

Fragmentation of monoclonal antibodies

(2011) Josef Vlasak et al.   mAbs

Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity

(2010) Sharon X. Gao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of an aqueous two-phase systems high-throughput screening method to evaluate mAb HCP separation

(2010) Stefan A. Oelmeier et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins

(2010) Haimanti Dorai et al.   BIOTECHNOLOGY PROGRESS

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway

(2010) James G. Barnard et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Degradation of an Fc-fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease

(2009) Flavie Robert et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein clearance during protein a chromatography: Development of an improved column wash step

(2008) Abhinav A. Shukla et al.   BIOTECHNOLOGY PROGRESS