Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

(2019) Lindsay F. Rizzardi et al.   NATURE NEUROSCIENCE

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

(2018) Rebecca G. Smith et al.   Alzheimers & Dementia

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

(2018) Jose V. Sanchez-Mut et al.   NATURE MEDICINE

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex

(2018) Kelly M. Bakulski et al.   JOURNAL OF ALZHEIMERS DISEASE

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

(2018) Gilles Gasparoni et al.   Epigenetics & Chromatin

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

(2018) Sarah J. Marzi et al.   NATURE NEUROSCIENCE

A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases

(2018) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

(2017) Diego Mastroeni et al.   PLoS One

Neuropathological and transcriptomic characteristics of the aged brain

(2017) Jeremy A Miller et al.   eLife

Exercise Plays a Preventive Role Against Alzheimer's Disease

(2017) Zsolt Radak et al.   JOURNAL OF ALZHEIMERS DISEASE

The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

(2016) Hans-Ulrich Klein et al.   ACTA NEUROPATHOLOGICA

Chromosome conformation elucidates regulatory relationships in developing human brain

(2016) Hyejung Won et al.   NATURE

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain

(2016) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

(2016) Simona Magi et al.   Biomed Research International

Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

(2016) J V Sanchez-Mut et al.   Translational Psychiatry

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Alterations in Alzheimer’s Disease

(2015) Jose V. Sanchez-Mut et al.   Frontiers in Behavioral Neuroscience

Tissue-Specific Effects of Genetic and Epigenetic Variation on Gene Regulation and Splicing

(2015) Maria Gutierrez-Arcelus et al.   PLoS Genetics

Cognitive Resilience to Apolipoprotein E ε4

(2015) Allison R. Kaup et al.   JAMA Neurology

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease

(2014) Jose Vicente Sanchez-Mut et al.   HIPPOCAMPUS

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition

(2014) Rahul Bharadwaj et al.   NEURON

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

(2014) Andrew E Jaffe et al.   GENOME BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

(2013) Jerry Guintivano et al.   Epigenetics

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons

(2013) Andrew S. P. Lim et al.   SLEEP

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Measuring cell-type specific differential methylation in human brain tissue

(2013) Carolina M Montaño et al.   GENOME BIOLOGY

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

(2012) Andrew E Jaffe et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

Cell adhesion molecules contribute to Alzheimer’s disease: multiple pathway analyses of two genome-wide association studies

(2011) Guiyou Liu et al.   JOURNAL OF NEUROCHEMISTRY

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One